Anti-TNF-Related Leukocytoclastic Vasculitis in Ulcerative Colitis: A Case Report.
leukocytoclastic vasculitis
purpura
tumor necrosis factor
ulcerative colitis
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
22 06 2021
22 06 2021
Historique:
received:
12
05
2021
revised:
12
06
2021
accepted:
17
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
8
2021
Statut:
epublish
Résumé
The development of drugs directed against tumor necrosis factor (TNF)-α has dramatically modified the therapeutic approach to inflammatory bowel diseases: a larger use of such drugs has also led to a major knowledge about their adverse effects, especially on skin. The aim of this report was to describe a rare steroid-dependent form of leukocytoclastic vasculitis induced by an anti-TNF-α agent in a young woman with ulcerative colitis. A young girl with ulcerative colitis developed a form of leukocytoclastic vasculitis induced by an anti-TNF-α agent. Recurrent palpable purpuric lesions on her legs were the main cutaneous manifestation. Skin lesions were steroid-dependent, but improved after withdrawal of the anti-TNF-α agent and second-line immunosuppressant therapy. The need to develop specific recommendations to guide the use of medications for managing skin reactions induced by anti-TNF-α drugs is herein emphasized.
Sections du résumé
BACKGROUND
The development of drugs directed against tumor necrosis factor (TNF)-α has dramatically modified the therapeutic approach to inflammatory bowel diseases: a larger use of such drugs has also led to a major knowledge about their adverse effects, especially on skin. The aim of this report was to describe a rare steroid-dependent form of leukocytoclastic vasculitis induced by an anti-TNF-α agent in a young woman with ulcerative colitis.
CASE PRESENTATION
A young girl with ulcerative colitis developed a form of leukocytoclastic vasculitis induced by an anti-TNF-α agent. Recurrent palpable purpuric lesions on her legs were the main cutaneous manifestation. Skin lesions were steroid-dependent, but improved after withdrawal of the anti-TNF-α agent and second-line immunosuppressant therapy.
CONCLUSIONS
The need to develop specific recommendations to guide the use of medications for managing skin reactions induced by anti-TNF-α drugs is herein emphasized.
Identifiants
pubmed: 34206410
pii: ijerph18136711
doi: 10.3390/ijerph18136711
pmc: PMC8297360
pii:
doi:
Substances chimiques
Tumor Necrosis Factor Inhibitors
0
Tumor Necrosis Factor-alpha
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Références
Mayo Clin Proc. 2012 Aug;87(8):739-45
pubmed: 22795634
Inflamm Bowel Dis. 2015 Aug;21(8):1982-92
pubmed: 26154136
Dermatol Ther. 2019 Nov;32(6):e13091
pubmed: 31579972
J Pediatr Gastroenterol Nutr. 2018 Aug;67(2):257-291
pubmed: 30044357
N Engl J Med. 2003 Feb 13;348(7):601-8
pubmed: 12584368
Expert Opin Investig Drugs. 2017 Apr;26(4):381-387
pubmed: 28277884
Gastroenterol Hepatol. 2013 Apr;36(4):296-7
pubmed: 23522950
Turk J Pediatr. 2019;61(3):386-391
pubmed: 31916716
Scand J Rheumatol. 2003;32(5):312-4
pubmed: 14690147
Expert Opin Drug Saf. 2020 Oct;19(10):1269-1301
pubmed: 32883123
Medicine (Baltimore). 2007 Jul;86(4):242-251
pubmed: 17632266
Gastroenterol Hepatol. 2018 Aug - Sep;41(7):442-443
pubmed: 29054318
Ann Dermatol. 2020 Feb;32(1):90-91
pubmed: 33911718
Front Pediatr. 2021 Feb 10;9:617312
pubmed: 33643972
Arch Dermatol. 2007 Feb;143(2):233-6
pubmed: 17310003
Intern Med. 2021 Feb 1;60(3):385-389
pubmed: 32863363
SAGE Open Med Case Rep. 2014 Aug 20;2:2050313X14547609
pubmed: 27489650
Expert Rev Clin Immunol. 2017 Jun;13(6):571-597
pubmed: 28064547
Inflamm Bowel Dis. 2011 Feb;17(2):E4-5
pubmed: 20848511
JAMA. 2017 Nov 7;318(17):1679-1686
pubmed: 29114832
Curr Rheumatol Rep. 2017 Oct 5;19(11):70
pubmed: 28983775
Curr Opin Rheumatol. 2005 Jan;17(1):56-61
pubmed: 15604905
J Pharm Pharm Sci. 2014;17(4):485-531
pubmed: 25579431
Dermatol Ther. 2020 May;33(3):e13294
pubmed: 32134546
Clin Gastroenterol Hepatol. 2016 Jan;14(1):e1-2
pubmed: 25998787
Joint Bone Spine. 2006 Dec;73(6):710-3
pubmed: 17127088
Inflamm Bowel Dis. 2009 Jan;15(1):63-8
pubmed: 18626963
Inflamm Bowel Dis. 2017 Jan;23(1):E1-E2
pubmed: 27893546
Graefes Arch Clin Exp Ophthalmol. 2018 Apr;256(4):801-808
pubmed: 29455252