The lncRNAs in HBV-Related HCCs: Targeting Chromatin Dynamics and Beyond.
HBV
HCC
LncRNAs
biomarkers
epigenetic regulation
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
22 Jun 2021
22 Jun 2021
Historique:
received:
19
04
2021
revised:
18
06
2021
accepted:
19
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Hepatocellular carcinoma (HCC) represents the fourth leading and fastest rising cause of cancer death (841,000 new cases and 782,000 deaths annually), and hepatitis B (HBV), with 250 million people chronically infected at risk of developing HCC, accounts for >50% of the cases worldwide. Long non-coding RNAs (lncRNAs), untranslated transcripts longer than 200 nucleotides, are implicated in gene regulation at the transcriptional and post-transcriptional levels, exerting their activities both in the nuclear and cytoplasmic compartments. Thanks to high-throughput sequencing techniques, several lncRNAs have been shown to favor the establishment of chronic HBV infection, to change the host transcriptome to establish a pro-carcinogenic environment, and to directly participate in HCC development and progression. In this review, we summarize current knowledge on the role of lncRNAs in HBV infection and HBV-related liver carcinogenesis and discuss the potential of lncRNAs as predictive or diagnostic biomarkers.
Identifiants
pubmed: 34206504
pii: cancers13133115
doi: 10.3390/cancers13133115
pmc: PMC8268133
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Agence Nationale de Recherches sur le Sida et les Hépatites Virales
ID : ECTZ66014, ECTZ143165, ECTZ160436
Organisme : Agence Nationale de Recherches sur le Sida et les Hépatites Virales
ID : ANR-16-IDEX-0005
Organisme : European Union
ID : EU H2020-667273-HEPCAR, EU H2020-847939-IP-cure-B
Organisme : Agence Nationale de Recherches sur le Sida et les Hépatites Virales
ID : ANR@TRACTION EpiVirHep
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