Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Pancreatic Cancer: Systematic Review and Still-Open Questions.
PD-1
PD-L1
TMB
TML
immunotherapy
pancreatic cancer
tumor mutation burden
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
22 Jun 2021
22 Jun 2021
Historique:
received:
18
05
2021
revised:
13
06
2021
accepted:
17
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Tumor mutational burden (TMB) is a numeric index that expresses the number of mutations per megabase (muts/Mb) harbored by tumor cells in a neoplasm. TMB can be determined using different approaches based on next-generation sequencing. In the case of high values, it indicates a potential response to immunotherapy. In this systematic review, we assessed the potential predictive role of high-TMB in pancreatic ductal adenocarcinoma (PDAC), as well as the histo-molecular features of high-TMB PDAC. High-TMB appeared as a rare but not-negligible molecular feature in PDAC, being present in about 1.1% of cases. This genetic condition was closely associated with mucinous/colloid and medullary histology (
Identifiants
pubmed: 34206554
pii: cancers13133119
doi: 10.3390/cancers13133119
pmc: PMC8269341
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 12182
Organisme : Fondazione Cariverona: Oncology Biobank Project "Antonio Schiavi"
ID : 203885/2017
Organisme : Fondazione Italiana Malattie Pancreas (FIMP-Ministero Salute)
ID : J38D19000690001
Organisme : Italian Ministry of Health
ID : RF CO-2019-12369662: CUP: B39C21000370001
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