Porcine Decellularized Diaphragm Hydrogel: A New Option for Skeletal Muscle Malformations.
diaphragmatic hernia
extracellular matrix
hydrogel
skeletal muscle
tissue engineering
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
22 Jun 2021
22 Jun 2021
Historique:
received:
26
05
2021
revised:
17
06
2021
accepted:
18
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Hydrogels are biomaterials that, thanks to their unique hydrophilic and biomimetic characteristics, are used to support cell growth and attachment and promote tissue regeneration. The use of decellularized extracellular matrix (dECM) from different tissues or organs significantly demonstrated to be far superior to other types of hydrogel since it recapitulates the native tissue's ECM composition and bioactivity. Different muscle injuries and malformations require the application of patches or fillers to replenish the defect and boost tissue regeneration. Herein, we develop, produce, and characterize a porcine diaphragmatic dECM-derived hydrogel for diaphragmatic applications. We obtain a tissue-specific biomaterial able to mimic the complex structure of skeletal muscle ECM; we characterize hydrogel properties in terms of biomechanical properties, biocompatibility, and adaptability for in vivo applications. Lastly, we demonstrate that dECM-derived hydrogel obtained from porcine diaphragms can represent a useful biological product for diaphragmatic muscle defect repair when used as relevant acellular stand-alone patch.
Identifiants
pubmed: 34206569
pii: biomedicines9070709
doi: 10.3390/biomedicines9070709
pmc: PMC8301461
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondazione Cassa di Risparmio di Padova e Rovigo
ID : Bando Ricerca Pediatrica 2016-2018
Organisme : Fondazione Istituto di Ricerca Pediatrica Città della Speranza
ID : Co-IRP grant
Organisme : Università degli Studi di Padova
ID : Bando Uni-Impresa 2018
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