Cytoprotective Effects of Fish Protein Hydrolysates against H
bioavailability
cytoprotective effect
cytotoxicity
fish hydrolysates
oxidative stress
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
18 Jun 2021
18 Jun 2021
Historique:
received:
12
05
2021
revised:
11
06
2021
accepted:
16
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Many studies report the potent antioxidant capacity for fish protein hydrolysates, including radical scavenging activity and inhibition ability on lipid peroxidation (LPO). In this study, the in vitro cytotoxicity of protein hydrolysates from different salmon, mackerel, and herring side streams fractions was evaluated in the concentration range from 1 to 1:32 dilution, using cloned human colon adenocarcinoma cells TC7 (Caco-2/TC7) by MTT and PT assays. The protein hydrolysates' antioxidant capacity and oxidative stress effects were evaluated by LPO and reactive oxygen species (ROS) generation, respectively. The antioxidant capacity for pure and bioavailable hydrolysate fraction was also evaluated and compared. Additionally, mycotoxin levels were determined in the fish protein hydrolysates, and their cytoprotective effect against T-2 toxin was evaluated. Both hydrolysates and their bioavailable fraction induced similar cell viability rates. The highest cytoprotective effect was obtained for the salmon viscera protein hydrolysate (HSV), which increased the cell viability by 51.2%. ROS accumulation induced by H
Identifiants
pubmed: 34207334
pii: antiox10060975
doi: 10.3390/antiox10060975
pmc: PMC8234493
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Bio-Based Industries Joint Undertaking
ID : 790956
Organisme : Conselleria d'Educació, Investigació, Cultura i Esport
ID : GV/2020/020
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