Contemporary Analysis of Electronic Frailty Measurement in Older Adults with Multiple Myeloma Treated in the National US Veterans Affairs Healthcare System.
frailty
frailty index
geriatric assessment
multiple myeloma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
18 Jun 2021
18 Jun 2021
Historique:
received:
12
05
2021
revised:
10
06
2021
accepted:
14
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Electronic frailty indices based on data from administrative claims and electronic health records can be used to estimate frailty in large populations of older adults with cancer where direct frailty measures are lacking. The objective of this study was to use the electronic Veterans Affairs Frailty Index (VA-FI-10)-developed and validated to measure frailty in the national United States (US) VA Healthcare System-to estimate the prevalence and impact of frailty in older US veterans newly treated for multiple myeloma (MM) with contemporary therapies. We designed a retrospective cohort study of 4924 transplant-ineligible veterans aged ≥ 65 years initiating MM therapy within VA from 2004 to 2017. Initial MM therapy was measured using inpatient and outpatient treatment codes from pharmacy data in the VA Corporate Data Warehouse. In total, 3477 veterans (70.6%) were classified as frail (VA-FI-10 > 0.2), with 1510 (30.7%) mildly frail (VA-FI-10 > 0.2-0.3), 1105 (22.4%) moderately frail (VA-FI-10 > 0.3-0.4), and 862 (17.5%) severely frail (VA-FI-10 > 0.4). Survival and time to hospitalization decreased with increasing VA-FI-10 severity (log-rank
Identifiants
pubmed: 34207459
pii: cancers13123053
doi: 10.3390/cancers13123053
pmc: PMC8233717
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : U.S. Department of Veterans Affairs
ID : IK2CX001800
Organisme : NIA NIH HHS
ID : R03AG060169
Pays : United States
Organisme : CSRD VA
ID : IK2 CX002218
Pays : United States
Organisme : CSRD VA
ID : IK2 CX001800
Pays : United States
Organisme : NCI NIH HHS
ID : P0115525807
Pays : United States
Organisme : NCI NIH HHS
ID : P50100707
Pays : United States
Organisme : NIA NIH HHS
ID : R33 AG057806
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG023480
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG060169
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA100707
Pays : United States
Organisme : VA Office of Research and Development, Cooperative Studies Program
ID : N/A
Organisme : BLRD VA
ID : I01 BX001584
Pays : United States
Organisme : U.S. Department of Veterans Affairs
ID : IK2CX002218
Organisme : NIA NIH HHS
ID : T32AG023480
Pays : United States
Organisme : VA Health Services Research and Development Service, VA Information Resource Center
ID : Project Numbers SDR 02-237 and 98-004
Organisme : NIA NIH HHS
ID : R33AG057806
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA155258
Pays : United States
Organisme : U.S. Department of Veterans Affairs
ID : I01BX001584
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