The Nature of Immune Responses to Influenza Vaccination in High-Risk Populations.
immunity
influenza
obesity
vaccine
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
09 06 2021
09 06 2021
Historique:
received:
27
04
2021
revised:
31
05
2021
accepted:
02
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
19
1
2022
Statut:
epublish
Résumé
The current pandemic has brought a renewed appreciation for the critical importance of vaccines for the promotion of both individual and public health. Influenza vaccines have been our primary tool for infection control to prevent seasonal epidemics and pandemics such as the 2009 H1N1 influenza A virus pandemic. Certain high-risk populations, including the elderly, people with obesity, and individuals with comorbidities such as type 2 diabetes mellitus, are more susceptible to increased disease severity and decreased vaccine efficacy. High-risk populations have unique microenvironments and immune responses that contribute to increased vulnerability for influenza infections. This review focuses on these differences as we investigate the variations in immune responses to influenza vaccination. In order to develop better influenza vaccines, it is critical to understand how to improve responses in our ever-growing high-risk populations.
Identifiants
pubmed: 34207924
pii: v13061109
doi: 10.3390/v13061109
pmc: PMC8228336
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Influenza Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI140766
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : 75N93019C0052
Organisme : National Institute of Allergy and Infectious Diseases
ID : HHSN27220140006C
Organisme : National Institute of Allergy and Infectious Diseases
ID : R01AI140766
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