An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach.
Animals
Disease Models, Animal
Female
Infectious Disease Transmission, Vertical
Magnetic Resonance Imaging
/ methods
Neurodevelopmental Disorders
/ diagnostic imaging
Neuroimaging
/ methods
Pregnancy
Pregnancy Complications, Infectious
/ diagnostic imaging
Rats
Zika Virus
/ pathogenicity
Zika Virus Infection
/ complications
MRI
Zika virus (ZIKV)
congenital infection
neurodevelopment
neuroimaging
pregnancy
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
11 06 2021
11 06 2021
Historique:
received:
10
03
2021
revised:
26
05
2021
accepted:
03
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Since Zika virus (ZIKV) first emerged as a public health concern in 2015, our ability to identify and track the long-term neurological sequelae of prenatal Zika virus (ZIKV) infection in humans has been limited. Our lab has developed a rat model of maternal ZIKV infection with associated vertical transmission to the fetus that results in significant brain malformations in the neonatal offspring. Here, we use this model in conjunction with longitudinal magnetic resonance imaging (MRI) to expand our understanding of the long-term neurological consequences of prenatal ZIKV infection in order to identify characteristic neurodevelopmental changes and track them across time. We exploited both manual and automated atlas-based segmentation of MR images in order to identify long-term structural changes within the developing rat brain following inoculation. The paradigm involved scanning three cohorts of male and female rats that were prenatally inoculated with 10
Identifiants
pubmed: 34207958
pii: v13061123
doi: 10.3390/v13061123
pmc: PMC8230645
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103653
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD096309
Pays : United States
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