Classification of Non-Small Cell Lung Cancer's Tumor Immune Micro-Environment and Strategies to Augment Its Response to Immune Checkpoint Blockade.
LUAD
LUSC
NSCLC
immune checkpoint blockade
tumor immune microenvironment
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 Jun 2021
11 Jun 2021
Historique:
received:
23
04
2021
revised:
03
06
2021
accepted:
09
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Immune checkpoint blockade (ICB) with checkpoint inhibitors has led to significant and durable response in a subset of patients with advanced stage EGFR and ALK wild-type non-small cell lung cancer (NSCLC). This has been consistently shown to be correlated with the unique characteristics of each patient's tumor immune micro-environment (TIME), including the composition and distribution of the tumor immune cell infiltrate; the expression of various checkpoints by tumor and immune cells, such as PD-L1; and the presence of various cytokines and chemokines. In this review, the classification of various types of TIME that are present in NSCLC and their correlation with response to ICB in NSCLC are discussed. This is conducted with a focus on the characteristics and identifiable biomarkers of different TIME subtypes that may also be used to predict NSCLC's clinical response to ICB. Finally, treatment strategies to augment response to ICB in NSCLC with unresponsive types of TIME are explored.
Identifiants
pubmed: 34208113
pii: cancers13122924
doi: 10.3390/cancers13122924
pmc: PMC8230820
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Cancer Immunol Res. 2015 Dec;3(12):1344-55
pubmed: 26253731
Cell. 2017 Feb 9;168(4):707-723
pubmed: 28187290
Cancer Cell. 2017 May 8;31(5):711-723.e4
pubmed: 28486109
Nature. 2018 Feb 22;554(7693):544-548
pubmed: 29443960
N Engl J Med. 2018 Jun 14;378(24):2288-2301
pubmed: 29863955
Clin Cancer Res. 2017 Sep 1;23(17):5024-5033
pubmed: 28512174
Cell Rep. 2015 May 19;11(7):1018-30
pubmed: 25959818
Sci Rep. 2020 Apr 30;10(1):7376
pubmed: 32355214
Mol Cancer Ther. 2019 Nov;18(11):2051-2062
pubmed: 31395688
J Clin Oncol. 2017 Dec 10;35(35):3924-3933
pubmed: 29023213
Cancer Res. 2011 May 15;71(10):3540-51
pubmed: 21430066
Nat Commun. 2020 Jan 30;11(1):603
pubmed: 32001676
Int J Cancer. 2017 Feb 15;140(4):888-899
pubmed: 27785783
JCI Insight. 2018 Oct 18;3(20):
pubmed: 30333313
Ann Oncol. 2019 Aug 1;30(8):1321-1328
pubmed: 31125062
Cancer Cell. 2019 Oct 14;36(4):385-401.e8
pubmed: 31564637
J Clin Oncol. 2020 May 10;38(14):1580-1590
pubmed: 32078391
J Thorac Oncol. 2019 Jun;14(6):1095-1101
pubmed: 30738221
Ann Oncol. 2020 Oct;31(10):1336-1349
pubmed: 32710930
JCI Insight. 2016 Jun 16;1(9):e87415
pubmed: 27699275
Cell Mol Immunol. 2020 Jan;17(1):1-12
pubmed: 31611651
Cancer Discov. 2017 Dec;7(12):1420-1435
pubmed: 29025772
J Thorac Oncol. 2017 May;12(5):814-823
pubmed: 28132868
Cancer Discov. 2017 Feb;7(2):128-130
pubmed: 28167612
Cancer Res. 2016 Jan 15;76(2):227-38
pubmed: 26637667
J Clin Invest. 2017 Aug 1;127(8):2930-2940
pubmed: 28650338
Cancer Discov. 2018 Jul;8(7):822-835
pubmed: 29773717
Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10119-E10126
pubmed: 30297397
Clin Cancer Res. 2016 Sep 15;22(18):4585-93
pubmed: 27225694
Science. 2015 Apr 3;348(6230):124-8
pubmed: 25765070
Cancer Res. 2016 Mar 1;76(5):999-1008
pubmed: 26833127
J Thorac Oncol. 2017 Feb;12(2):208-222
pubmed: 27913228
J Immunol. 2018 Jan 15;200(2):422-431
pubmed: 29311384
Lancet. 2016 Apr 9;387(10027):1540-1550
pubmed: 26712084
Cancer Res. 2015 Jun 1;75(11):2139-45
pubmed: 25977340
J Immunother Cancer. 2019 Jun 25;7(1):160
pubmed: 31238970
Ann Oncol. 2019 Feb 1;30(2):219-235
pubmed: 30608567
Br J Cancer. 2020 Aug;123(3):392-402
pubmed: 32433601
Clin Cancer Res. 2019 Aug 1;25(15):4663-4673
pubmed: 31053602
Clin Cancer Res. 2017 Jan 15;23(2):370-378
pubmed: 27440266
Clin Cancer Res. 2015 Sep 1;21(17):4014-21
pubmed: 26019170
Lancet Respir Med. 2019 May;7(5):387-401
pubmed: 30922878
Nat Med. 2007 Jul;13(7):828-35
pubmed: 17603493
Nat Immunol. 2019 Mar;20(3):326-336
pubmed: 30778252
Sci Transl Med. 2017 Apr 12;9(385):
pubmed: 28404866
Cancer Med. 2020 Jun;9(12):4386-4394
pubmed: 32333643
Oncoimmunology. 2021 Jan 20;10(1):1873607
pubmed: 33537176
Oncogene. 2018 Apr;37(17):2302-2312
pubmed: 29422611
J Clin Invest. 2017 Apr 3;127(4):1425-1437
pubmed: 28319047
Clin Cancer Res. 2018 Jul 1;24(13):3087-3096
pubmed: 29615460
Cancer Lett. 2020 Feb 1;470:95-105
pubmed: 31644929
J Thorac Oncol. 2020 Apr;15(4):628-636
pubmed: 31945494
Clin Cancer Res. 2017 Jun 15;23(12):3203-3213
pubmed: 28302866
PLoS One. 2012;7(3):e32542
pubmed: 22396773
Sci Adv. 2021 Feb 3;7(6):
pubmed: 33536206
N Engl J Med. 2018 Nov 22;379(21):2040-2051
pubmed: 30280635
J Thorac Oncol. 2020 May;15(5):777-791
pubmed: 32068166
Immunity. 2014 Nov 20;41(5):843-52
pubmed: 25517616
Cancer Discov. 2012 Aug;2(8):722-35
pubmed: 22822050
Blood. 2018 Sep 13;132(11):1146-1158
pubmed: 30054295
Ther Adv Med Oncol. 2018 Jan 18;10:1758834017749748
pubmed: 29383037
Expert Opin Ther Targets. 2017 Oct;21(10):959-966
pubmed: 28831824
Front Immunol. 2018 May 03;9:978
pubmed: 29774034
Nat Med. 2014 Jun;20(6):607-15
pubmed: 24793239
Ann Oncol. 2016 Aug;27(8):1492-504
pubmed: 27207108
J Clin Invest. 2019 Feb 25;129(4):1551-1565
pubmed: 30694219
Ann Oncol. 2019 May 1;30(5):839-844
pubmed: 30847464
Lancet. 2016 Sep 3;388(10048):1012-24
pubmed: 27598681
EBioMedicine. 2019 Sep;47:235-246
pubmed: 31462392
Nat Rev Cancer. 2019 Sep;19(9):495-509
pubmed: 31406302
Oncoimmunology. 2019 Nov 2;9(1):1682380
pubmed: 32002289
Immunity. 2019 Jan 15;50(1):195-211.e10
pubmed: 30635237
J Thorac Oncol. 2018 Sep;13(9):1363-1372
pubmed: 29802888
Trends Cancer. 2016 Jun;2(6):286-294
pubmed: 27774519
Nat Rev Cancer. 2020 Jan;20(1):12-25
pubmed: 31806885
J Exp Med. 2011 Sep 26;208(10):1949-62
pubmed: 21930770
Cancer Discov. 2020 Dec;10(12):1826-1841
pubmed: 33071215
Cancer Immunol Res. 2016 Oct;4(10):858-868
pubmed: 27549123
N Engl J Med. 2020 Oct 1;383(14):1328-1339
pubmed: 32997907
Cytokine Growth Factor Rev. 2010 Feb;21(1):49-59
pubmed: 20018551
N Engl J Med. 2016 Nov 10;375(19):1823-1833
pubmed: 27718847
Clin Cancer Res. 2020 Feb 15;26(4):970-977
pubmed: 31615933
Cancer Discov. 2016 Aug;6(8):827-37
pubmed: 27301722
J Clin Invest. 2018 Feb 1;128(2):580-588
pubmed: 29337303
Nature. 2018 Feb 22;554(7693):538-543
pubmed: 29443964
Nat Med. 2018 Dec;24(12):1845-1851
pubmed: 30397353
Nature. 2014 Nov 27;515(7528):568-71
pubmed: 25428505
Clin Cancer Res. 2017 Sep 15;23(18):5514-5526
pubmed: 28533222
Lancet. 2017 Jan 21;389(10066):255-265
pubmed: 27979383
Immunity. 2019 Jan 15;50(1):181-194.e6
pubmed: 30635236
Clin Cancer Res. 2020 Mar 15;26(6):1420-1431
pubmed: 31848188
Clin Cancer Res. 2012 Aug 1;18(15):4037-47
pubmed: 22696230
Oncogene. 2017 Sep 14;36(37):5285-5295
pubmed: 28504720
Cancer Biol Med. 2014 Sep;11(3):173-81
pubmed: 25364578
Nature. 2014 Nov 27;515(7528):563-7
pubmed: 25428504
Clin Cancer Res. 2019 May 15;25(10):3074-3083
pubmed: 30635339
JCO Precis Oncol. 2019;3:
pubmed: 31192313
JAMA Oncol. 2015 Dec;1(9):1325-32
pubmed: 26270858
J Thorac Oncol. 2018 Aug;13(8):1138-1145
pubmed: 29874546
Ann Oncol. 2020 Apr;31(4):507-516
pubmed: 32139298
Cell Rep. 2019 Oct 29;29(5):1236-1248.e7
pubmed: 31665636
FASEB J. 2015 Jan;29(1):227-38
pubmed: 25361735
J Clin Invest. 2007 Dec;117(12):3846-56
pubmed: 18060032
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2823-8
pubmed: 25730849
J Thorac Oncol. 2018 May;13(5):682-688
pubmed: 29518553
Clin Cancer Res. 2021 Mar 15;27(6):1720-1733
pubmed: 33323404
Int J Radiat Oncol Biol Phys. 2016 Dec 1;96(5):934-936
pubmed: 27869095
J Clin Invest. 2019 Dec 2;129(12):5553-5567
pubmed: 31710313
Nat Commun. 2017 Jun 09;8:15618
pubmed: 28598415
Trends Immunol. 2018 Jul;39(7):536-548
pubmed: 29751996
Cancer Immunol Immunother. 2017 Sep;66(9):1175-1187
pubmed: 28451792
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4575-4582
pubmed: 30760587
Cancer Discov. 2017 Feb;7(2):188-201
pubmed: 27903500
Mol Ther. 2018 Nov 7;26(11):2567-2579
pubmed: 30274786
Cancer Discov. 2017 Mar;7(3):264-276
pubmed: 28031159
Nat Med. 2018 Sep;24(9):1441-1448
pubmed: 30082870
J Immunother Cancer. 2015 Dec 15;3:51
pubmed: 26674411
Clin Cancer Res. 2016 May 15;22(10):2329-34
pubmed: 27016309
N Engl J Med. 2018 Dec 13;379(24):2342-2350
pubmed: 30280658
Clin Cancer Res. 2018 Nov 15;24(22):5710-5723
pubmed: 29764856
J Natl Cancer Inst. 2018 Jul 1;110(7):787-790
pubmed: 29365144
N Engl J Med. 2018 May 31;378(22):2093-2104
pubmed: 29658845
J Exp Med. 2019 Oct 7;216(10):2394-2411
pubmed: 31375534
Science. 2016 Mar 25;351(6280):1463-9
pubmed: 26940869
J Thorac Oncol. 2014 Jun;9(6):794-804
pubmed: 24828662
Sci Transl Med. 2020 Oct 14;12(565):
pubmed: 33055240
Immunity. 2018 Apr 17;48(4):812-830.e14
pubmed: 29628290
Cancer Res. 2021 Jan 15;81(2):248-253
pubmed: 33087323
Front Immunol. 2019 Oct 15;10:2453
pubmed: 31681327
J Immunother Cancer. 2020 May;8(1):
pubmed: 32461344
Front Immunol. 2020 Dec 14;11:594609
pubmed: 33381115
Ann Oncol. 2019 Aug 1;30(8):1311-1320
pubmed: 31086949
Nature. 2015 Nov 12;527(7577):249-53
pubmed: 26503055
JCI Insight. 2019 Dec 19;4(24):
pubmed: 31852845
J Immunother Cancer. 2019 Nov 21;7(1):313
pubmed: 31753019
J Thorac Oncol. 2015 Jun;10(6):910-23
pubmed: 25658629
J Thorac Oncol. 2021 Apr;16(4):583-600
pubmed: 33388477
PLoS One. 2019 May 24;14(5):e0216864
pubmed: 31125352
Immunity. 2019 Apr 16;50(4):924-940
pubmed: 30995507
N Engl J Med. 2016 May 12;374(19):1864-73
pubmed: 27168435
J Thorac Oncol. 2019 Nov;14(11):1924-1934
pubmed: 31323387
Nat Med. 2018 Jul;24(7):994-1004
pubmed: 29892065
Front Immunol. 2019 Feb 08;10:168
pubmed: 30800125
Lancet. 2016 Apr 30;387(10030):1837-46
pubmed: 26970723
Cancer Immunol Res. 2017 Feb;5(2):127-136
pubmed: 28077434
J Immunother Cancer. 2018 Jun 4;6(1):47
pubmed: 29866156
Trends Immunol. 2010 Jun;31(6):220-7
pubmed: 20538542
Mol Cancer Ther. 2012 Feb;11(2):485-91
pubmed: 22135231
Cancer Res. 2019 Jul 1;79(13):3251-3267
pubmed: 31040157
N Engl J Med. 2018 May 31;378(22):2078-2092
pubmed: 29658856
Oncoimmunology. 2017 Jul 26;6(11):e1356145
pubmed: 29147605
J Thorac Oncol. 2010 Feb;5(2):153-7
pubmed: 20101143
Cancer Immunol Res. 2018 Jan;6(1):14-24
pubmed: 29097422
J Thorac Oncol. 2017 Feb;12(2):171-172
pubmed: 28115107
Cancer Immunol Immunother. 2020 Sep;69(9):1929-1936
pubmed: 32435850
Nat Commun. 2016 Feb 17;7:10501
pubmed: 26883990
Nat Commun. 2018 Aug 29;9(1):3506
pubmed: 30158636
Oncol Lett. 2021 Mar;21(3):203
pubmed: 33574942
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
Cancer Discov. 2016 Feb;6(2):202-16
pubmed: 26645196
Ann Oncol. 2017 Jul 1;28(7):1532-1539
pubmed: 28407039
Br J Cancer. 2020 Jun;122(12):1732-1743
pubmed: 32327707
Clin Cancer Res. 2020 Nov 1;26(21):5701-5708
pubmed: 32709715
Nat Rev Cancer. 2012 Mar 22;12(4):252-64
pubmed: 22437870
Clin Cancer Res. 2018 Apr 15;24(8):1954-1964
pubmed: 29374053
J Immunother Cancer. 2020 Jul;8(2):
pubmed: 32727812
Nat Commun. 2017 Nov 10;8(1):1404
pubmed: 29123081
J Clin Oncol. 2018 Mar 1;36(7):633-641
pubmed: 29337640
Cancer Res. 2017 Dec 15;77(24):6795-6811
pubmed: 29247038
Oncoimmunology. 2017 Feb 21;6(4):e1294299
pubmed: 28507803
J Clin Invest. 2014 Jun;124(6):2425-40
pubmed: 24812664
Cancer Cell. 2014 Dec 8;26(6):923-937
pubmed: 25465800
Science. 2018 Mar 23;359(6382):1350-1355
pubmed: 29567705
Clin Cancer Res. 2013 Sep 15;19(18):4917-24
pubmed: 23868869
Sci Rep. 2019 Mar 18;9(1):4761
pubmed: 30886380
Trends Immunol. 2018 Aug;39(8):644-655
pubmed: 30001871
J Thorac Oncol. 2019 Nov;14(11):1881-1883
pubmed: 31668314
Commun Biol. 2020 Feb 25;3(1):85
pubmed: 32099064
Mol Cancer Ther. 2021 Jan;20(1):121-131
pubmed: 33277440
Oncoimmunology. 2017 Jul 13;6(10):e1349589
pubmed: 29123964
N Engl J Med. 2017 Jun 22;376(25):2415-2426
pubmed: 28636851
Lung Cancer. 2018 Nov;125:115-120
pubmed: 30429008
J Thorac Oncol. 2018 Dec;13(12):1884-1896
pubmed: 30267840
Oncogene. 2010 Sep 16;29(37):5159-70
pubmed: 20562917
N Engl J Med. 2016 Nov 3;375(18):1767-1778
pubmed: 27806234
Lancet. 2019 May 4;393(10183):1819-1830
pubmed: 30955977
Cancer Discov. 2019 Jan;9(1):34-45
pubmed: 30297358
Cancer Discov. 2013 Dec;3(12):1355-63
pubmed: 24078774
J Exp Med. 2015 Feb 9;212(2):139-48
pubmed: 25601652
Nature. 2015 Jul 9;523(7559):231-5
pubmed: 25970248
J Immunother Cancer. 2020 Feb;8(1):
pubmed: 32079617
Nature. 2019 Mar;567(7749):479-485
pubmed: 30894752
J Exp Med. 2006 May 15;203(5):1259-71
pubmed: 16636135
Cancer Immunol Immunother. 2020 May;69(5):771-777
pubmed: 32047958
Cancer Immunol Res. 2019 Mar;7(3):510-525
pubmed: 30728151
J Clin Oncol. 2004 Mar 15;22(6):1136-51
pubmed: 15020616
Ann Oncol. 2020 Dec;31(12):1746-1754
pubmed: 32866624
J Immunother Cancer. 2020 Oct;8(2):
pubmed: 33106387