Modulation of Glutamate Transporter EAAT1 and Inward-Rectifier Potassium Channel K
Animals
Anti-Bacterial Agents
/ pharmacology
Astrocytes
/ drug effects
Cell Separation
Cells, Cultured
Excitatory Amino Acid Transporter 1
/ metabolism
Female
Glial Fibrillary Acidic Protein
/ metabolism
Male
Minocycline
/ pharmacology
Platinum
/ pharmacology
Potassium Channels, Inwardly Rectifying
/ metabolism
Rats, Wistar
Spinal Cord
/ cytology
EAAT1
GFAP
Kir4.1
astrocytes
chemotherapy-induced neuropathy
cisplatin
oxaliplatin
potassium channel
spinal cord
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Jun 2021
11 Jun 2021
Historique:
received:
30
04
2021
revised:
06
06
2021
accepted:
09
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
15
7
2021
Statut:
epublish
Résumé
Platinum-based chemotherapeutics still play an essential role in cancer treatment. Despite their high effectiveness, severe side effects such as chemotherapy-induced neuropathy (CIPN) occur frequently. The pathophysiology of CIPN by platinum-based chemotherapeutics is not fully understood yet, but primarily the disturbance of dorsal root ganglion cells is discussed. However, there is increasing evidence of central nervous system involvement with activation of spinal cord astrocytes after treatment with chemotherapeutics. We investigated the influence of cis- or oxaliplatin on the functionality of cultured rat spinal cord astrocytes by using immunocytochemistry and patch-clamp electrophysiology. Cis- or oxaliplatin activated spinal astrocytes and led to downregulation of the excitatory amino acid transporter 1 (EAAT1) expression. Furthermore, the expression and function of potassium channel K
Identifiants
pubmed: 34208258
pii: ijms22126300
doi: 10.3390/ijms22126300
pmc: PMC8230757
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Excitatory Amino Acid Transporter 1
0
Glial Fibrillary Acidic Protein
0
Kcnj10 (channel)
0
Potassium Channels, Inwardly Rectifying
0
Platinum
49DFR088MY
Minocycline
FYY3R43WGO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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