An Antigenic Thrift-Based Approach to Influenza Vaccine Design.
antigenic drift
antigenic thrift
evolutionary theory
influenza
vaccination
vaccine
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
16 Jun 2021
16 Jun 2021
Historique:
received:
16
04
2021
revised:
04
06
2021
accepted:
05
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
The antigenic drift theory states that influenza evolves via the gradual accumulation of mutations, decreasing a host's immune protection against previous strains. Influenza vaccines are designed accordingly, under the premise of antigenic drift. However, a paradox exists at the centre of influenza research. If influenza evolved primarily through mutation in multiple epitopes, multiple influenza strains should co-circulate. Such a multitude of strains would render influenza vaccines quickly inefficacious. Instead, a single or limited number of strains dominate circulation each influenza season. Unless additional constraints are placed on the evolution of influenza, antigenic drift does not adequately explain these observations. Here, we explore the constraints placed on antigenic drift and a competing theory of influenza evolution - antigenic thrift. In contrast to antigenic drift, antigenic thrift states that immune selection targets epitopes of limited variability, which constrain the variability of the virus. We explain the implications of antigenic drift and antigenic thrift and explore their current and potential uses in the context of influenza vaccine design.
Identifiants
pubmed: 34208489
pii: vaccines9060657
doi: 10.3390/vaccines9060657
pmc: PMC8235769
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : 75N93019C00076
Pays : United States
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