Interventricular Differences of Signaling Pathways-Mediated Regulation of Cardiomyocyte Function in Response to High Oxidative Stress in the Post-Ischemic Failing Rat Heart.
Ca2+-sensitivity
CaMKII
HFrEF
PKG
cardiomyocyte
diastolic dysfunction
heart failure
myofilament proteins
oxidative stress
passive stiffness
right ventricle
titin
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
16 Jun 2021
16 Jun 2021
Historique:
received:
07
04
2021
revised:
20
05
2021
accepted:
08
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Standard heart failure (HF) therapies have failed to improve cardiac function or survival in HF patients with right ventricular (RV) dysfunction suggesting a divergence in the molecular mechanisms of RV vs. left ventricular (LV) failure. Here we aimed to investigate interventricular differences in sarcomeric regulation and function in experimental myocardial infarction (MI)-induced HF with reduced LV ejection fraction (HFrEF). MI was induced by LAD ligation in Sprague-Dawley male rats. Sham-operated animals served as controls. Eight weeks after intervention, post-ischemic HFrEF and Sham animals were euthanized. Heart tissue samples were deep-frozen stored (
Identifiants
pubmed: 34208541
pii: antiox10060964
doi: 10.3390/antiox10060964
pmc: PMC8234177
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : (HA 7512/2-1 and HA 7512/2-4)
Organisme : Heinrich und Alma Vogelsang Stiftung and German Academic Exchange Service
ID : DAAD
Organisme : The Ministry of Human Capacities of Hungary
ID : GINOP-2.3.2-15-2016-00043 project
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