Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections.

Gram-negative Staphylococcus aureus Staphylococcus pseudintermedius antimicrobial resistance benzguinols bioluminescent mouse model colistin cytotoxicity minimum inhibitory concentration nidulins

Journal

Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404

Informations de publication

Date de publication:
16 Jun 2021
Historique:
received: 12 05 2021
revised: 10 06 2021
accepted: 10 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Our recent focus on the "lost antibiotic" unguinol and related nidulin-family fungal natural products identified two semisynthetic derivatives, benzguinols A and B, with unexpected in vitro activity against

Identifiants

pubmed: 34208698
pii: antibiotics10060727
doi: 10.3390/antibiotics10060727
pmc: PMC8233939
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Cooperative Research Centres, Australian Government Department of Industry
ID : CRCPFIVE000119

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Auteurs

Hang Thi Nguyen (HT)

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, SA 5371, Australia.
Department of Pharmacology, Toxicology, Internal Medicine and Diagnostics, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.

Mahmud T Morshed (MT)

Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.

Daniel Vuong (D)

Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia.

Andrew Crombie (A)

Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia.

Ernest Lacey (E)

Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.
Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia.

Sanjay Garg (S)

Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.

Hongfei Pi (H)

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, SA 5371, Australia.

Lucy Woolford (L)

School of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, SA 5371, Australia.

Henrietta Venter (H)

Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.

Stephen W Page (SW)

Advanced Veterinary Therapeutics, Newtown, NSW 2042, Australia.

Andrew M Piggott (AM)

Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.

Darren J Trott (DJ)

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, SA 5371, Australia.

Abiodun D Ogunniyi (AD)

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, SA 5371, Australia.

Classifications MeSH