Characterization of Glycosphingolipids in the Human Parathyroid and Thyroid Glands.
blood group antigens
glycosphingolipid characterization
mass spectrometry
parathyroid glycosphingolipids
thyroid glycosphingolipids
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jun 2021
30 Jun 2021
Historique:
received:
12
05
2021
revised:
15
06
2021
accepted:
23
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
30
7
2021
Statut:
epublish
Résumé
As part of a systematic investigation of the glycosphingolipids in human tissues, acid and non-acid glycosphingolipids from human thyroid and parathyroid glands were isolated and characterized with mass spectrometry and binding of carbohydrate-recognizing ligands, with a focus on complex compounds. The glycosphingolipid patterns of the human parathyroid and thyroid glands were very similar. The major acid glycosphingolipids were sulfatide and the gangliosides GM3, GD3, GD1a, GD1b, GT1b and Neu5Ac-neolactotetraosylceramide, and the major non-acid glycosphingolipids were globotriaosylceramide and globoside. We also found neolactotetra- and neolactohexaosylceramide, the x
Identifiants
pubmed: 34208903
pii: ijms22137044
doi: 10.3390/ijms22137044
pmc: PMC8269270
pii:
doi:
Substances chimiques
Blood Group Antigens
0
Gangliosides
0
Glycosphingolipids
0
Ligands
0
ganglioside, GD1a
12707-58-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swedish Cancer Foundation
ID : 200759
Organisme : Goran Gustafsson Foundation
Organisme : Lisa och Johan Grönbergs Stiftelse
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