Copy Number Alteration Profile Provides Additional Prognostic Value for Acute Lymphoblastic Leukemia Patients Treated on BFM Protocols.
MLPA
acute lymphoblastic leukemia
child
copy number alterations (CNAs)
genetics
minimal residual disease
risk stratification
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 06 2021
30 06 2021
Historique:
received:
10
05
2021
revised:
25
06
2021
accepted:
25
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
We present our data of a novel proposed CNA-profile risk-index, applied on a Greek ALLIC-BFM-treated cohort, aiming at further refining genomic risk-stratification. Eighty-five of 227 consecutively treated ALL patients were analyzed for the copy-number-status of eight genes (IKZF1/CDKN2A/2B/PAR1/BTG1/EBF1/PAX5/ETV6/RB1). Using the MLPA-assay, patients were stratified as: (1) Good-risk(GR)-CNA-profile (
Identifiants
pubmed: 34209196
pii: cancers13133289
doi: 10.3390/cancers13133289
pmc: PMC8268490
pii:
doi:
Types de publication
Journal Article
Langues
eng
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