Consequences and Resolution of Transcription-Replication Conflicts.
G-MiDS
MIDAS
R-loops
chromatin
common fragile sites
early replicating fragile sites
fork reversal
genomic instability
replication stress
torsional stress
transcription–replication conflicts
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
30 Jun 2021
30 Jun 2021
Historique:
received:
16
05
2021
revised:
28
06
2021
accepted:
28
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Transcription-replication conflicts occur when the two critical cellular machineries responsible for gene expression and genome duplication collide with each other on the same genomic location. Although both prokaryotic and eukaryotic cells have evolved multiple mechanisms to coordinate these processes on individual chromosomes, it is now clear that conflicts can arise due to aberrant transcription regulation and premature proliferation, leading to DNA replication stress and genomic instability. As both are considered hallmarks of aging and human diseases such as cancer, understanding the cellular consequences of conflicts is of paramount importance. In this article, we summarize our current knowledge on where and when collisions occur and how these encounters affect the genome and chromatin landscape of cells. Finally, we conclude with the different cellular pathways and multiple mechanisms that cells have put in place at conflict sites to ensure the resolution of conflicts and accurate genome duplication.
Identifiants
pubmed: 34209204
pii: life11070637
doi: 10.3390/life11070637
pmc: PMC8303131
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : H2020 European Research Council
ID : 852798
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