Changes in HMO Concentrations throughout Lactation: Influencing Factors, Health Effects and Opportunities.
2′-fucosyllactose
breast milk
gut microbiota
lacto-N-neotetraose
maternal origin
secretor and Lewis blood type
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
30 Jun 2021
30 Jun 2021
Historique:
received:
24
05
2021
revised:
28
06
2021
accepted:
28
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
28
7
2021
Statut:
epublish
Résumé
Human milk oligosaccharides (HMOs) are important functional biomolecules in human breast milk. Understanding the factors influencing differences in HMO composition and changes in their concentration over lactation can help to design feeding strategies that are well-adapted to infant's needs. This review summarises the total and individual concentration of HMOs from data published from 1999 to 2019. Studies show that the HMO concentrations are highest in colostrum (average 9-22 g/L), followed by slightly lower concentrations in transitional milk (average 8-19 g/L), with a gradual decline in mature milk as lactation progresses, from 6-15 g/L in breast milk collected within one month of birth, to 4-6 g/L after 6 months. Significant differences in HMO composition have been described between countries. Different HMOs were shown to be predominant over the course of lactation, e.g., 3-fucosyllactose increased over lactation, whereas 2'-fucosyllactose decreased. Recent clinical studies on infant formula supplemented with 2'-fucosyllactose in combination with other oligosaccharides showed its limited beneficial effect on infant health.
Identifiants
pubmed: 34209241
pii: nu13072272
doi: 10.3390/nu13072272
pmc: PMC8308359
pii:
doi:
Substances chimiques
Oligosaccharides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Beijing Yili Technology Development Co
ID : N/A
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