Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-oxadiazole-2-thiol Scaffold.
1,3,4-oxadiazole-2-thiol
cyclooxygenase
docking study
indomethacin
inflammation
nitric oxide
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jun 2021
30 Jun 2021
Historique:
received:
25
05
2021
revised:
25
06
2021
accepted:
25
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
22
7
2021
Statut:
epublish
Résumé
Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing indomethacin derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs,
Identifiants
pubmed: 34209248
pii: ijms22137079
doi: 10.3390/ijms22137079
pmc: PMC8267937
pii:
doi:
Substances chimiques
Oxadiazoles
0
1,3,4-oxadiazole
20O2F20OUR
Nitric Oxide
31C4KY9ESH
Cyclooxygenase 2
EC 1.14.99.1
PTGS2 protein, human
EC 1.14.99.1
Indomethacin
XXE1CET956
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : AUF-IFA
ID : 28/2019
Organisme : University of Medicine and Pharmacy "Grigore T. Popa" of Iasi
ID : 6985/2020
Organisme : FEDER under projects Valbiocosm FEDER-FSE
ID : 2017-EX003202
Organisme : CHembio FEDER-FSE 2014-2020-EX003677
ID : EX003677
Organisme : Techsab FEDER-FSE 2014-2020-EX011313
ID : EX011313
Organisme : the SFR neuroimagerie (SFR FED 4224), the Labex programs SYNORG
ID : ANR-11-LABX-0029
Organisme : IRON
ID : ANR-11-LABX-0018-01
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