Organoprotective Effects of Spironolactone on Top of Ramipril Therapy in a Mouse Model for Alport Syndrome.
hereditary kidney disease
nephroprotective therapy
progressive kidney fibrosis
type IV collagen
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
30 Jun 2021
30 Jun 2021
Historique:
received:
16
05
2021
revised:
17
06
2021
accepted:
29
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Angiotensin-converting enzyme inhibitors (ACEi) delay progression of the inherited renal disease Alport syndrome. However, the effect of ACEis weakens gradually due to an "aldosterone escape". Here, we investigate if an aldosterone antagonist can counteract loss of ACEi-efficacy.
Identifiants
pubmed: 34209341
pii: jcm10132958
doi: 10.3390/jcm10132958
pmc: PMC8268845
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GR 1852/6-1 to O.G.
Organisme : K. C. Wong Education Foundation
ID : to Y. Zhang
Organisme : Deutscher Akademischer Austauschdienst
ID : to Y. Zhang
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