Biological Effects of XyloCore, a Glucose Sparing PD Solution, on Mesothelial Cells: Focus on Mesothelial-Mesenchymal Transition, Inflammation and Angiogenesis.
Biomarkers
/ metabolism
Cell Line
Cell Shape
/ drug effects
Cell Survival
/ drug effects
Cell Transdifferentiation
/ drug effects
Dialysis Solutions
/ pharmacology
Electric Impedance
Epithelial Cells
/ drug effects
Epithelium
/ drug effects
Glucose
/ pharmacology
Human Umbilical Vein Endothelial Cells
/ cytology
Humans
Inflammation
/ pathology
Mesoderm
/ drug effects
Mitochondria
/ drug effects
Neovascularization, Physiologic
/ drug effects
Oxidative Stress
/ drug effects
Peritoneal Dialysis
Permeability
Snail Family Transcription Factors
/ genetics
Transforming Growth Factor beta
/ genetics
Vascular Endothelial Growth Factor A
/ metabolism
L-carnitine
Xylitol
biocompatible solutions
fibrosis
peritoneal dialysis
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
30 Jun 2021
30 Jun 2021
Historique:
received:
28
05
2021
revised:
25
06
2021
accepted:
29
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
28
7
2021
Statut:
epublish
Résumé
Glucose-based solutions remain the most used osmotic agents in peritoneal dialysis (PD), but unavoidably they contribute to the loss of peritoneal filtration capacity. Here, we evaluated at a molecular level the effects of XyloCore, a new PD solution with a low glucose content, in mesothelial and endothelial cells. Cell viability, integrity of mesothelial and endothelial cell membrane, activation of mesothelial and endothelial to mesenchymal transition programs, inflammation, and angiogenesis were evaluated by several techniques. Results showed that XyloCore preserves mesothelial and endothelial cell viability and membrane integrity. Moreover XyloCore, unlike glucose-based solutions, does not exert pro-fibrotic, -inflammatory, and -angiogenic effects. Overall, the in vitro evidence suggests that XyloCore could represent a potential biocompatible solution promising better outcomes in clinical practice.
Identifiants
pubmed: 34209455
pii: nu13072282
doi: 10.3390/nu13072282
pmc: PMC8308380
pii:
doi:
Substances chimiques
Biomarkers
0
Dialysis Solutions
0
Snail Family Transcription Factors
0
Transforming Growth Factor beta
0
Vascular Endothelial Growth Factor A
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Nephrol Dial Transplant. 2012 Mar;27(3):937-46
pubmed: 21856758
J Am Soc Nephrol. 2011 Sep;22(9):1682-95
pubmed: 21742730
BMC Nephrol. 2015 Apr 14;16:53
pubmed: 25885318
Kidney Int. 2018 Dec;94(6):1227-1237
pubmed: 30360960
Kidney Int. 2011 Sep;80(6):645-54
pubmed: 21525850
Nephrol Dial Transplant. 2007 Jan;22(1):53-8
pubmed: 17050633
Kidney Blood Press Res. 2017;42(2):209-219
pubmed: 28478435
Am J Nephrol. 2010;31(1):58-67
pubmed: 19887789
Drug Des Devel Ther. 2016 Nov 28;10:3925-3932
pubmed: 27932866
Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F310-F318
pubmed: 28490530
Mediators Inflamm. 2012;2012:912595
pubmed: 22547910
Nephrology (Carlton). 2005 Jun;10(3):234-9
pubmed: 15958035
Perit Dial Int. 2012 May-Jun;32(3):292-304
pubmed: 22215656
Pediatr Nephrol. 2017 Oct;32(10):1835-1843
pubmed: 27722783
Molecules. 2019 Sep 23;24(19):
pubmed: 31547545
J Am Soc Nephrol. 2002 Feb;13(2):470-479
pubmed: 11805177
Cancer Treat Res. 2007;134:1-19
pubmed: 17633044
Kidney Int. 2005 Apr;67(4):1559-65
pubmed: 15780112
Perit Dial Int. 2000;20 Suppl 2:S19-25
pubmed: 10911638
J Am Soc Nephrol. 2010 Jul;21(7):1077-85
pubmed: 20448020
Front Physiol. 2019 Jan 07;9:1853
pubmed: 30700974
Immunity. 2014 Jan 16;40(1):40-50
pubmed: 24412616
J Nephrol. 2021 Apr;34(2):503-519
pubmed: 32767274
Kidney Int. 2018 Aug;94(2):419-429
pubmed: 29776755
Perit Dial Int. 2012 Jul-Aug;32(4):453-61
pubmed: 22215657
Am J Nephrol. 2018;47(5):317-324
pubmed: 29779030
Adv Chronic Kidney Dis. 2007 Jul;14(3):269-78
pubmed: 17603981
Kidney Int. 1993 Jan;43(1):226-33
pubmed: 8433563
Cochrane Database Syst Rev. 2014 Mar 27;(3):CD007554
pubmed: 24671928
Perit Dial Int. 1999 Nov-Dec;19(6):517-25
pubmed: 10641771
Am J Respir Crit Care Med. 2002 Jan 1;165(1):88-94
pubmed: 11779736
Clin J Am Soc Nephrol. 2015 Aug 7;10(8):1380-8
pubmed: 26048890
Kidney Int Suppl. 2003 Dec;(88):S43-9
pubmed: 14870877
Int Urol Nephrol. 2018 Mar;50(3):495-500
pubmed: 28674854
Perit Dial Int. 2006 Mar-Apr;26(2):162-73
pubmed: 16623418
Perit Dial Int. 2009 Feb;29 Suppl 2:S108-10
pubmed: 19270196
Perit Dial Int. 2000;20 Suppl 5:S10-8
pubmed: 11229606
Perit Dial Int. 2007 Jun;27 Suppl 2:S87-93
pubmed: 17556337
Exp Cell Res. 2016 Feb 1;341(1):42-53
pubmed: 26825654
Clin J Am Soc Nephrol. 2015 Nov 6;10(11):1990-2001
pubmed: 26463882
Kidney Int. 2016 Mar;89(3):625-35
pubmed: 26880457
Kidney Int. 2013 Nov;84(5):969-79
pubmed: 23698236
Kidney Int. 2004 Jul;66(1):408-18
pubmed: 15200450
Kidney Int. 1998 Dec;54(6):2207-17
pubmed: 9853287
Kidney Int Suppl. 2008 Apr;(108):S131-6
pubmed: 18379536
Nephrol Dial Transplant. 2009 Sep;24(9):2899-908
pubmed: 19258384
Nephron. 1996;72(2):171-6
pubmed: 8684522
Toxins (Basel). 2021 Feb 24;13(3):
pubmed: 33668249
PLoS One. 2013 Apr 09;8(4):e60776
pubmed: 23585849
Nephrol Dial Transplant. 2017 Jul 1;32(7):1145-1154
pubmed: 28064160
J Am Soc Nephrol. 2007 Jul;18(7):2004-13
pubmed: 17568021
Am J Kidney Dis. 2003 Jul;42(1):173-83
pubmed: 12830470
Microvasc Res. 2004 Mar;67(2):117-24
pubmed: 15020202
Am J Kidney Dis. 2005 Nov;46(5):938-48
pubmed: 16253736
J Lab Clin Med. 1999 Aug;134(2):124-32
pubmed: 10444025
N Engl J Med. 2003 Jan 30;348(5):403-13
pubmed: 12556543
Methods Enzymol. 2014;542:243-62
pubmed: 24862270
Semin Nephrol. 2017 Jan;37(1):30-42
pubmed: 28153193
Perit Dial Int. 1999 May-Jun;19(3):221-30
pubmed: 10433158
Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F338-F353
pubmed: 31841386
J Am Soc Nephrol. 2001 Aug;12(8):1734-1741
pubmed: 11461947
Biomolecules. 2020 Dec 15;10(12):
pubmed: 33334074
Front Physiol. 2017 Jun 13;8:379
pubmed: 28659813
Am J Kidney Dis. 2013 Nov;62(5):929-38
pubmed: 23725973
Biochim Biophys Acta. 2016 Oct;1863(10):2422-35
pubmed: 26828774
Nephrol Dial Transplant. 2001 May;16(5):905-12
pubmed: 11328894
J Biomed Biotechnol. 2011;2011:180594
pubmed: 22203782
Beijing Da Xue Xue Bao Yi Xue Ban. 2017 Dec 18;49(6):954-960
pubmed: 29263464
Perit Dial Int. 2002 Jan-Feb;22(1):11-21
pubmed: 11929138
Clin Chim Acta. 2013 Jun 5;421:46-50
pubmed: 23466603
PLoS One. 2016 Oct 21;11(10):e0165045
pubmed: 27768727
Exp Mol Pathol. 2017 Jun;102(3):377-383
pubmed: 28347704
Perit Dial Int. 2002 Mar-Apr;22(2):171-7
pubmed: 11990400
Int J Mol Sci. 2020 Dec 24;22(1):
pubmed: 33374405
Front Pharmacol. 2015 Jun 09;6:113
pubmed: 26106328
J Ren Nutr. 2013 May;23(3):237-40
pubmed: 23611553
Trans Am Soc Artif Intern Organs. 1982;28:280-6
pubmed: 6761936
Kidney Int. 2002 Feb;61(2):570-8
pubmed: 11849398
Int J Mol Sci. 2020 Aug 13;21(16):
pubmed: 32823722
J Clin Med Res. 2011 May 19;3(3):132-8
pubmed: 21811544
Kidney Int. 2018 Aug;94(2):246-248
pubmed: 30031446
Front Med. 2017 Sep;11(3):349-358
pubmed: 28791669
Biochem Biophys Res Commun. 1995 Aug 15;213(2):630-8
pubmed: 7544124
Perit Dial Int. 2015 Mar-Apr;35(2):147-58
pubmed: 25904773
Cell Signal. 2020 Nov;75:109778
pubmed: 32926960
Clin J Am Soc Nephrol. 2010 Apr;5(4):723-32
pubmed: 20093342
J Lab Clin Med. 2001 Feb;137(2):125-32
pubmed: 11174469
Perit Dial Int. 2000 Nov-Dec;20(6):798-801
pubmed: 11216582
Antioxidants (Basel). 2021 Mar 13;10(3):
pubmed: 33805753
Am J Nephrol. 2014;39(6):459-65
pubmed: 24854010