Determination of Non-Invasive Biomarkers for the Assessment of Fibrosis, Steatosis and Hepatic Iron Overload by MR Image Analysis. A Pilot Study.
biomarker
fibrosis
hepatic iron overload
image analysis
magnetic resonance protocol
phantom
steatosis
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
29 Jun 2021
29 Jun 2021
Historique:
received:
12
05
2021
revised:
06
06
2021
accepted:
25
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
The reference diagnostic test of fibrosis, steatosis, and hepatic iron overload is liver biopsy, a clear invasive procedure. The main objective of this work was to propose HSA, or human serum albumin, as a biomarker for the assessment of fibrosis and to study non-invasive biomarkers for the assessment of steatosis and hepatic iron overload by means of an MR image acquisition protocol. It was performed on a set of eight subjects to determine fibrosis, steatosis, and hepatic iron overload with four different MRI sequences. We calibrated longitudinal relaxation times (
Identifiants
pubmed: 34209547
pii: diagnostics11071178
doi: 10.3390/diagnostics11071178
pmc: PMC8307019
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Conselleria d'Educació, Investigació, Cultura i Esport
ID : AEST/2019/037
Organisme : Conselleria d'Educació, Investigació, Cultura i Esport
ID : AEST/2020/029
Organisme : Agència Valenciana de la Innovació
ID : INNCAD00/19/085
Organisme : Agència Valenciana de la Innovació
ID : INNCAD/2020/84
Organisme : Centro para el Desarrollo Tecnológico Industrial
ID : CIIP-20192020
Références
Clin Gastroenterol Hepatol. 2021 Apr;19(4):797-805.e7
pubmed: 32450363
Lancet. 2004 Jan 31;363(9406):357-62
pubmed: 15070565
Magn Reson Imaging Clin N Am. 2010 Aug;18(3):337-57, ix
pubmed: 21094444
Diagn Interv Imaging. 2013 Jul-Aug;94(7-8):713-27
pubmed: 23751229
J Hepatol. 2019 Jan;70(1):151-171
pubmed: 30266282
Eur Radiol. 2012 Nov;22(11):2478-86
pubmed: 22645044
Ann Hepatol. 2018 Jun 4;17(4):547-560
pubmed: 29893696
Radiographics. 2009 Oct;29(6):1653-64
pubmed: 19959513
Abdom Imaging. 2015 Apr;40(4):766-75
pubmed: 25805619
Diagnostics (Basel). 2021 Apr 26;11(5):
pubmed: 33926073
Radiology. 2020 Sep;296(3):532-540
pubmed: 32573385
World J Gastroenterol. 2014 Jul 14;20(26):8393-406
pubmed: 25024597
Arch Surg. 2002 Nov;137(11):1305-10
pubmed: 12413326
Rev Gastroenterol Mex. 2017 Jan - Mar;82(1):32-45
pubmed: 28089429
Can J Gastroenterol. 2007 Feb;21(2):101-4
pubmed: 17299614
N Engl J Med. 2001 Feb 15;344(7):495-500
pubmed: 11172192
Virchows Arch. 1997 Mar;430(3):195-207
pubmed: 9099976
World J Hepatol. 2015 Aug 18;7(17):2069-79
pubmed: 26301049
Clin Res Hepatol Gastroenterol. 2012 Feb;36(1):13-20
pubmed: 21920839
Biomed Res Int. 2015;2015:874201
pubmed: 25866819
J Hepatol. 2009 Dec;51(6):1061-7
pubmed: 19846234
Hepat Mon. 2014 Jan 03;14(1):e15167
pubmed: 24497882
Radiology. 2013 May;267(2):422-31
pubmed: 23382291
J Magn Reson Imaging. 2008 Sep;28(3):543-58
pubmed: 18777528
Eur Radiol. 2018 May;28(5):2022-2030
pubmed: 29178028
JACC Cardiovasc Imaging. 2016 Jan;9(1):67-81
pubmed: 26762877
Magn Reson Imaging. 1991;9(6):975-8
pubmed: 1766326
Insights Imaging. 2012 Apr;3(2):173-80
pubmed: 22696043