Prognostic Value of PD-L1, PD-1 and CD8A in Canine Diffuse Large B-Cell Lymphoma Detected by RNAscope.

PD-1 PD-L1 RNAscope diffuse large B-cell lymphoma dog

Journal

Veterinary sciences
ISSN: 2306-7381
Titre abrégé: Vet Sci
Pays: Switzerland
ID NLM: 101680127

Informations de publication

Date de publication:
29 Jun 2021
Historique:
received: 27 05 2021
revised: 24 06 2021
accepted: 28 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Immune checkpoints are a set of molecules dysregulated in several human and canine cancers and aberrations of the PD-1/PD-L1 axis are often correlated with a worse prognosis. To gain an insight into the role of immune checkpoints in canine diffuse large B-cell lymphoma (cDLBCL), we investigated PD-L1, PD-1 and CD8A expression by RNAscope. Results were correlated with several clinico-pathological features, including treatment, Ki67 index and outcome. A total of 33 dogs treated with chemotherapy (

Identifiants

pubmed: 34209830
pii: vetsci8070120
doi: 10.3390/vetsci8070120
pmc: PMC8310184
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Italian Ministry of Health
ID : RC IZS VE 04/2020

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Auteurs

Luca Aresu (L)

Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy.

Laura Marconato (L)

Department of Medical Veterinary Science, University of Bologna, 40064 Ozzano dell'Emilia, Italy.

Valeria Martini (V)

Department of Veterinary Medicine, University of Milan, 26900 Lodi, Italy.

Antonella Fanelli (A)

Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy.

Luca Licenziato (L)

Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy.

Greta Foiani (G)

Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), 35020 Legnaro, Italy.

Erica Melchiotti (E)

Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), 35020 Legnaro, Italy.

Arturo Nicoletti (A)

Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy.

Marta Vascellari (M)

Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), 35020 Legnaro, Italy.

Classifications MeSH