Molecular and Circulating Biomarkers of Brain Tumors.
brain tumor
tumor markers
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Jun 2021
29 Jun 2021
Historique:
received:
09
06
2021
revised:
27
06
2021
accepted:
27
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
28
7
2021
Statut:
epublish
Résumé
Brain tumors are the most common malignant primary intracranial tumors of the central nervous system. They are often recognized too late for successful therapy. Minimally invasive methods are needed to establish a diagnosis or monitor the response to treatment of CNS tumors. Brain tumors release molecular information into the circulation. Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a substitute for tumor tissue. Tumor-derived biomarkers include nucleic acids, proteins, and tumor-derived extracellular vesicles that accumulate in blood or cerebrospinal fluid. In recent years, circulating tumor cells have also been identified in the blood of glioblastoma patients. In this review of the literature, the authors highlight the significance, regulation, and prevalence of molecular biomarkers such as O
Identifiants
pubmed: 34210107
pii: ijms22137039
doi: 10.3390/ijms22137039
pmc: PMC8268709
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
O(6)-Methylguanine-DNA Methyltransferase
EC 2.1.1.63
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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