Association of Fusobacterium nucleatum infection and colorectal cancer: A Mexican study.
Asociación entre infección por Fusobacterium nucleatum y cáncer colorrectal: un estudio mexicano.
Citocinas
Colorectal cancer
Cytokines
Cáncer colorrectal
Fusobacterium nucleatum
Inflamación
Inflammation
Microbiota
Journal
Revista de gastroenterologia de Mexico (English)
ISSN: 2255-534X
Titre abrégé: Rev Gastroenterol Mex (Engl Ed)
Pays: Mexico
ID NLM: 101778603
Informations de publication
Date de publication:
28 Jun 2021
28 Jun 2021
Historique:
received:
29
09
2020
revised:
19
11
2020
accepted:
09
12
2020
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
aheadofprint
Résumé
Colorectal cancer (CRC) is the third most prevalent cancer worldwide. Many risk factors are involved, and current evidence links the gut microbiota and colorectal carcinogenesis. Fusobacterium nucleatum is proposed as one of the risk factors at the onset and during the progression of CRC, due to immune system and inflammatory modulation. Ninety samples from three different regions of the colon were collected through colonoscopy in patients with CRC, and qPCR TagMan® was conducted to detect F. nucleatum and cytokines (IL-17, IL-23, and IL-10) in tumor, peritumor, and normal samples. The differences between them were analyzed and correlated. The abundance of F. nucleatum determined through the 2 CRC is a heterogeneous disease that presents and progresses in a complex microenvironment, partially due to gut microbiome imbalance. F. nucleatum was enriched in CRC tissue, but whether that is a cause of the pathology or a consequence, has not yet been clearly defined.
Identifiants
pubmed: 34210555
pii: S0375-0906(21)00035-5
doi: 10.1016/j.rgmx.2020.12.002
pii:
doi:
Types de publication
Journal Article
Langues
eng
spa
Informations de copyright
Copyright © 2021 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.