Spindle assembly checkpoint activation and silencing at kinetochores.
Aneuploidy
Catalysis
Checkpoint
Chromosome segregation
Kinetochores
Mitosis
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
10
05
2021
revised:
17
06
2021
accepted:
17
06
2021
pubmed:
3
7
2021
medline:
17
2
2022
entrez:
2
7
2021
Statut:
ppublish
Résumé
The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of kinetochores, the proteinaceous structures that assemble onto chromosomes in mitosis in order to mediate their interaction with spindle microtubules. When unattached, kinetochores generate a diffusible inhibitor that blocks the activity of the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase required for sister chromatid separation and exit from mitosis. Work from the past decade has greatly illuminated our understanding of the mechanisms by which the diffusible inhibitor is assembled and how it inhibits the APC/C. However, less is understood about how SAC proteins are recruited to kinetochores in the absence of microtubule attachment, how the kinetochore catalyzes formation of the diffusible inhibitor, and how attachments silence the SAC at the kinetochore. Here, we summarize current understanding of the mechanisms that activate and silence the SAC at kinetochores and highlight open questions for future investigation.
Identifiants
pubmed: 34210579
pii: S1084-9521(21)00160-9
doi: 10.1016/j.semcdb.2021.06.009
pmc: PMC8406419
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-98Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM074215
Pays : United States
Organisme : Cancer Research UK
ID : C29/A24397
Pays : United Kingdom
Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.
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