Follow-up of children with sickle cell anemia screened with transcranial Doppler and enrolled in a primary prevention program of ischemic stroke.
Hydroxyurea
Primary prevention
Sickle cell anemia
Stroke
Transcranial Doppler
Journal
Hematology, transfusion and cell therapy
ISSN: 2531-1387
Titre abrégé: Hematol Transfus Cell Ther
Pays: Brazil
ID NLM: 101725732
Informations de publication
Date de publication:
Historique:
received:
15
02
2021
revised:
08
05
2021
accepted:
17
05
2021
pubmed:
3
7
2021
medline:
3
7
2021
entrez:
2
7
2021
Statut:
ppublish
Résumé
Stroke is a serious complication of sickle cell anemia (SCA). The transcranial Doppler (TCD) is the risk-screening tool for ischemic strokes. The objective of the study was to describe the clinical progression of children with SCA who presented with high risk for stroke by TCD or relevant changes by magnetic resonance angiography (MRA) and underwent the regular transfusion program (RTP) and/or hydroxyurea (HU) treatment between 2007 and 2018. This was a neonatal retrospective/prospective cohort study with children born between 1999 and 2014 with the homozygotic form (HbSS) or Sβ Of the 718 children screened during this period, 675 had HbSS and 43 Sβ The TCD was confirmed as a viable tool for tracking patients with a risk for stroke. The RTP was effective in preventing the primary event. New strategies are necessary to prevent stroke using HU and new drugs, in addition to bone marrow transplantation.
Sections du résumé
BACKGROUND
BACKGROUND
Stroke is a serious complication of sickle cell anemia (SCA). The transcranial Doppler (TCD) is the risk-screening tool for ischemic strokes. The objective of the study was to describe the clinical progression of children with SCA who presented with high risk for stroke by TCD or relevant changes by magnetic resonance angiography (MRA) and underwent the regular transfusion program (RTP) and/or hydroxyurea (HU) treatment between 2007 and 2018.
METHOD
METHODS
This was a neonatal retrospective/prospective cohort study with children born between 1999 and 2014 with the homozygotic form (HbSS) or Sβ
RESULTS
RESULTS
Of the 718 children screened during this period, 675 had HbSS and 43 Sβ
CONCLUSIONS
CONCLUSIONS
The TCD was confirmed as a viable tool for tracking patients with a risk for stroke. The RTP was effective in preventing the primary event. New strategies are necessary to prevent stroke using HU and new drugs, in addition to bone marrow transplantation.
Identifiants
pubmed: 34210619
pii: S2531-1379(21)00081-X
doi: 10.1016/j.htct.2021.05.001
pmc: PMC9605893
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
478-484Informations de copyright
Copyright © 2021 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest The authors report no conflicts of interest.
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