Diabetes Mellitus and Cognition: Pathway Analysis in the MEMENTO Cohort.
Aged
Aged, 80 and over
Alzheimer Disease
/ diagnosis
Amyloid beta-Peptides
/ cerebrospinal fluid
Biomarkers
Cerebral Small Vessel Diseases
/ diagnosis
Cognitive Dysfunction
/ diagnosis
Cohort Studies
Comorbidity
Diabetes Mellitus
/ diagnosis
Female
France
/ epidemiology
Humans
Magnetic Resonance Imaging
Male
Nerve Degeneration
/ diagnosis
Neuropsychological Tests
Positron-Emission Tomography
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
24 08 2021
24 08 2021
Historique:
received:
06
12
2020
accepted:
25
05
2021
pubmed:
3
7
2021
medline:
4
9
2021
entrez:
2
7
2021
Statut:
ppublish
Résumé
To assess the role of biomarkers of Alzheimer disease (AD), neurodegeneration, and small vessel disease (SVD) as mediators in the association between diabetes mellitus and cognition. The study sample was derived from MEMENTO, a cohort of French adults recruited in memory clinics and screened for either isolated subjective cognitive complaints or mild cognitive impairment. Diabetes was defined based on blood glucose assessment, use of antidiabetic agent, or self-report. We used structural equation modeling to assess whether latent variables of AD pathology (PET mean amyloid uptake, Aβ There were 254 (11.1%) participants with diabetes among 2,288 participants (median age 71.6 years; 61.8% women). The association between diabetes and lower cognition was significantly mediated by higher neurodegeneration (standardized indirect effect: -0.061, 95% confidence interval: -0.089, -0.032), but not mediated by SVD and AD markers. Results were similar when considering latent variables of memory or executive functioning. In a large clinical cohort in the elderly, diabetes is associated with lower cognition through neurodegeneration, independently of SVD and AD biomarkers.
Identifiants
pubmed: 34210821
pii: WNL.0000000000012440
doi: 10.1212/WNL.0000000000012440
pmc: PMC8397583
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e836-e848Investigateurs
Michèle Allard
(M)
Sandrine Andrieu
(S)
Pierre Anthony
(P)
Christine Astier
(C)
Alexandre Augier
(A)
Nicolas Auguste
(N)
Sophie Auriacombe
(S)
John Avet
(J)
Olivier Bailon
(O)
Fabrice-Guy Barral
(FG)
Jean Barré
(J)
Annick Barthelaix
(A)
Catherine Bayle
(C)
Olivier Beauchet
(O)
Samia Belkacem
(S)
Douraied Ben Salem
(D)
Karim Bennys
(K)
Géraldine Bera
(G)
Eric Berger
(E)
Marc G Berger
(MG)
Emilie Bergouin
(E)
François Bertin-Hugault
(F)
Guillaume Bertrand
(G)
François-Xavier Bertrand
(FX)
Catherine Beze
(C)
Valérie Boilet
(V)
Alain Bonafé
(A)
Yasmina Boudali
(Y)
Hatem Bouhladour
(H)
Clémence Boully
(C)
Vincent Bouteloup
(V)
Claire Boutet
(C)
Serge Bracard
(S)
Antoine Brangier
(A)
Pierre-Yves Brillet
(PY)
Laure Caillard
(L)
Fabienne Calvas
(F)
Agnès Camus
(A)
Vincent Camus
(V)
Sandrine Canaple
(S)
Antoine Carpentier
(A)
Pascaline Cassagnaud
(P)
Françoise Cattin
(F)
Ludivine Chamard
(L)
Stéphane Chanalet
(S)
Mathieu Chastan
(M)
Sophie Chauvelier
(S)
Valérie Chauvire
(V)
Samia Cheriet
(S)
Anthony Clotagatide
(A)
Emmanuel Cognat
(E)
Lora Cohen
(L)
Jean-Marc Constans
(JM)
Marie-Hélène Coste
(MH)
Jean-Philippe Cottier
(JP)
François Cotton
(F)
Isabelle Couret
(I)
Olivier-François Couturier
(OF)
Pascale Cowppli-Bony
(P)
Véronique Cressot
(V)
Benjamin Crétin
(B)
Keren Danaila
(K)
Jacques Darcourt
(J)
Jean-François Dartigues
(JF)
Ana-Maria Dascalita
(AM)
Renaud David
(R)
Xavier De Petigny
(X)
Delphine De Verbizier-Lonjon
(D)
Marielle Decousus
(M)
Isabelle Defouilloy
(I)
Christine Delmaire
(C)
Julien Delrieu
(J)
Catherine Demuyinck
(C)
Vincent Deramecourt
(V)
Hervé Deramond
(H)
Thomas Desmidt
(T)
Marie-Dominique Desruet
(MD)
Julien Detour
(J)
Agnès Devendeville
(A)
Mira Didic
(M)
Maritchu Doireau
(M)
Antonio Dos Santos
(AD)
Patrice Douillet
(P)
Foucaud Du Boisgueheneuc
(F)
Delphine Dubail
(D)
Laure Ducroq-Ducastaing
(L)
Julien Dumurgier
(J)
Diane Dupuy
(D)
Emmanuelle Duron
(E)
Inna Dygai-Cochet
(I)
Véronique Eder
(V)
Stéphane Epelbaum
(S)
Frédérique Etcharry-Bouyx
(F)
Daniel Fagret
(D)
Catherine Faisant
(C)
Karim Farid
(K)
Denis Fédérico
(D)
Olivier Felician
(O)
Philippe Fernandez
(P)
Pacôme Fosse
(P)
Alexandra Foubert-Samier
(A)
Isabelle Franck
(I)
Monique Galitzky
(M)
Céline Gallazzini-Crepin
(C)
Radka Gantchev
(R)
Laurence Garbarg-Chenon
(L)
Guillaume Gautier
(G)
Emmanuel Gerardin
(E)
Claire Gervais
(C)
Jean-Claude Getenet
(JC)
Nadine Girard
(N)
Fabienne Giraud
(F)
Chantal Girtanner
(C)
Valérie Gissot
(V)
Caroline Grangeon
(C)
Daniel Grucker
(D)
Eric Guedj
(E)
Claude Gueriot
(C)
Yves Guilhermet
(Y)
Rémy Guillevin
(R)
Sophie Haffen
(S)
Didier Hannequin
(D)
Sandrine Harston
(S)
Anne Hitzel
(A)
Caroline Hommet
(C)
Claude Hossein-Foucher
(C)
Fabrice Hubele
(F)
Agnès Jacquin-Piques
(A)
Betty Jean
(B)
Joanne Jenn
(J)
Laure Joly
(L)
Thérèse Jonveaux
(T)
Adrien Julian
(A)
Aurélie Kas
(A)
Anna Kearney-Schwartz
(A)
Alice Keles
(A)
Antony Kelly
(A)
Nathalie Keromnes
(N)
Lejla Koric
(L)
Alexandre Krainik
(A)
Stéphane Kremer
(S)
Florian Labourée
(F)
Franck Lacoeuille
(F)
Francoise Lala
(F)
Chantal Lamy
(C)
Jean-Louis Laplanche
(JL)
Cyrille Launay
(C)
Stéphane Lehericy
(S)
Sylvain Lehmann
(S)
Hermine Lenoir
(H)
Marcel Levy
(M)
Stéphanie Libercier
(S)
Marie-Anne Mackowiak-Cordoliani
(MA)
Eloi Magnin
(E)
Zaza Makaroff
(Z)
Athina Marantidou
(A)
Isabelle Marcet
(I)
Cécilia Marelli
(C)
Sophie Marilier
(S)
Idalie Martin
(I)
Olivier Martinaud
(O)
Catherine Martin-Hunyadi
(C)
Aïcha Medjoul
(A)
Isabelle Merlet
(I)
Danielle Mestas
(D)
Marc-Etienne Meyer
(ME)
Jean-Marc Michel
(JM)
Agnès Michon
(A)
Isabelle Migeon-Duballet
(I)
Karl Mondon
(K)
Clément Morgat
(C)
Véronique Moullart
(V)
Christian Moussard
(C)
Aurélie Mouton
(A)
Izzie Jacques Namer
(IJ)
Georges Niewiadomski
(G)
Guillaume Nivaggioni
(G)
Marie Noblet
(M)
Michel Nonent
(M)
Fati Nourhashemi
(F)
Hélène Oesterle
(H)
Galdric Orvoen
(G)
Amandine Pallardy
(A)
Pierre-Yves Pare
(PY)
Anne Pasco
(A)
Pierre Payoux
(P)
Cécile Pays
(C)
Isabelle Pellegrin
(I)
Rémy Perdrisot
(R)
Bertille Perin
(B)
Christine Perret-Guillaume
(C)
Grégory Petyt
(G)
Nathalie Philippi
(N)
Geneviève Pinganaud
(G)
Matthieu Plichart
(M)
Gabriel Pop
(G)
Michèle Puel
(M)
Mathieu Queneau
(M)
Solène Querellou
(S)
Muriel Quillard-Muraine
(M)
Valérie Quipourt
(V)
Chloé Rachez
(C)
Micheline Razzouk-Cadet
(M)
Anne-Sophie Rigaud
(AS)
Hélène Robin-Ismer
(H)
Mathieu Rodallec
(M)
Yves Rolland
(Y)
Adeline Rollin-Sillaire
(A)
Olivier Rouaud
(O)
Caroline Roubaud
(C)
Isabelle Rouch
(I)
Julie Roux
(J)
Guillaume Sacco
(G)
Pierre-Yves Salaun
(PY)
François Salmon
(F)
Alicia Sanchez
(A)
Maria-Joao Santiago-Ribeiro
(MJ)
Alain Sarciron
(A)
Nathalie Sastre-Hengan
(N)
Christian Scheiber
(C)
Anne-Marie Schneider
(AM)
Franck Semah
(F)
Amélie Serra
(A)
Marie-Laure Seux
(ML)
Hélène Sordet-Guépet
(H)
Maria Eugenia Soto
(ME)
Mathieu Tafani
(M)
Jean-Yves Tanguy
(JY)
Michael Taroux
(M)
Marc Teichmann
(M)
Catherine Terrat
(C)
Jamila Thabet
(J)
Claire Thalamas
(C)
Catherine Thomas-Anterion
(C)
Anne-Cécile Troussière
(AC)
Renata Ursu
(R)
Pierre Vera
(P)
Martine Vercelletto
(M)
Olivier Vercruysse
(O)
Antoine Verger
(A)
Philippe Viau
(P)
Marie-Neige Videau
(MN)
Thierry Voisin
(T)
Nathalie Wagemann
(N)
Aziza Waissi-Sediq
(A)
Jing Xie
(J)
Nathanaëlle Yeni
(N)
Michel Zanca
(M)
Jean Zinszner
(J)
Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
Références
Neurology. 2019 Feb 19;92(8):e823-e830
pubmed: 30674592
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
PLoS One. 2012;7(11):e48953
pubmed: 23152828
Neuroinformatics. 2016 Jul;14(3):253-64
pubmed: 27066973
Neurology. 2016 Aug 9;87(6):595-600
pubmed: 27385744
Diabetes Care. 2013 Dec;36(12):4036-42
pubmed: 23939539
JAMA Neurol. 2013 Sep 1;70(9):1167-72
pubmed: 23897112
Diabetes Care. 2017 Nov;40(11):1514-1521
pubmed: 28916531
J Neuroimaging. 2005 Oct;15(4):348-55
pubmed: 16254400
Neuroimage. 2004 Aug;22(4):1732-43
pubmed: 15275929
Diabetes Care. 2013 Jan;36(1):90-7
pubmed: 22933440
Diabetes Care. 2016 Feb;39(2):300-7
pubmed: 26681727
Neuroimage. 2005 Jul 1;26(3):839-51
pubmed: 15955494
Ann Neurol. 2014 Jan;75(1):138-46
pubmed: 24243491
Int Psychogeriatr. 2010 Sep;22(6):984-94
pubmed: 20594384
J Nucl Med. 2014 May;55(5):759-64
pubmed: 24652830
Neurobiol Dis. 2015 Dec;84:22-38
pubmed: 25926349
JAMA Neurol. 2015 Sep;72(9):1013-20
pubmed: 26214150
Neurology. 2015 Sep 29;85(13):1123-30
pubmed: 26333802
Diabetes Care. 2019 Jul;42(7):1248-1254
pubmed: 31221696
Alzheimers Dement (Amst). 2017 Nov 23;10:94-98
pubmed: 29255789
Nat Rev Endocrinol. 2018 Oct;14(10):591-604
pubmed: 30022099
Neuroimage. 2009 Jul 1;46(3):749-61
pubmed: 19236922
Annu Rev Public Health. 2016;37:17-32
pubmed: 26653405
Am J Psychol. 1987 Fall-Winter;100(3-4):587-609
pubmed: 3322058
Alzheimers Res Ther. 2017 Aug 29;9(1):67
pubmed: 28851447
EJNMMI Phys. 2016 Dec;3(1):6
pubmed: 27044410
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Alzheimers Dement. 2019 Jan;15(1):25-33
pubmed: 30114414
Ann Nucl Med. 2018 Feb;32(2):75-86
pubmed: 29218458
Arch Clin Neuropsychol. 2004 Mar;19(2):203-14
pubmed: 15010086
Front Neurosci. 2018 Apr 10;12:215
pubmed: 29743868
J Alzheimers Dis. 2017;59(2):405-419
pubmed: 28527209
Cerebrovasc Dis. 2002;13 Suppl 2:31-6
pubmed: 11901240
J Alzheimers Dis. 2017;59(2):421-432
pubmed: 28269785
Arch Neurol. 1978 Jun;35(6):364-7
pubmed: 655909
Neuroimage. 2012 Nov 1;63(2):936-46
pubmed: 22510256
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
Neurology. 1988 Jun;38(6):900-3
pubmed: 3368071
Clin Geriatr Med. 2015 Feb;31(1):101-15, ix
pubmed: 25453304
Alzheimers Dement. 2017 Mar;13(3):247-256
pubmed: 27521789