Astrocytes close the mouse critical period for visual plasticity.
Animals
Astrocytes
/ metabolism
Connexin 30
/ metabolism
Critical Period, Psychological
Enzyme Activation
GTP Phosphohydrolases
/ metabolism
Interneurons
/ metabolism
Matrix Metalloproteinase 9
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Neuronal Plasticity
Synapses
/ metabolism
Visual Cortex
/ growth & development
rhoA GTP-Binding Protein
/ metabolism
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
02 07 2021
02 07 2021
Historique:
received:
01
11
2020
accepted:
13
05
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
14
7
2021
Statut:
ppublish
Résumé
Brain postnatal development is characterized by critical periods of experience-dependent remodeling of neuronal circuits. Failure to end these periods results in neurodevelopmental disorders. The cellular processes defining critical-period timing remain unclear. Here, we show that in the mouse visual cortex, astrocytes control critical-period closure. We uncover the underlying pathway, which involves astrocytic regulation of the extracellular matrix, allowing interneuron maturation. Unconventional astrocyte connexin signaling hinders expression of extracellular matrix-degrading enzyme matrix metalloproteinase 9 (MMP9) through RhoA-guanosine triphosphatase activation. Thus, astrocytes not only influence the activity of single synapses but also are key elements in the experience-dependent wiring of brain circuits.
Identifiants
pubmed: 34210880
pii: 373/6550/77
doi: 10.1126/science.abf5273
doi:
Substances chimiques
Connexin 30
0
Gjb6 protein, mouse
0
Matrix Metalloproteinase 9
EC 3.4.24.35
Mmp9 protein, mouse
EC 3.4.24.35
GTP Phosphohydrolases
EC 3.6.1.-
RhoA protein, mouse
EC 3.6.5.2
rhoA GTP-Binding Protein
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-81Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.