Effect of Perioperative Fluids on Serum Osmolality and Serum Sodium in Patients Undergoing Transcranial Excision of Craniopharyngioma: A Prospective Randomized Controlled Trial.
0.45% sodium chloride solution
balanced salt solution
craniopharyngioma
diabetes insipidus
hypernatremia
Journal
Asian journal of neurosurgery
ISSN: 1793-5482
Titre abrégé: Asian J Neurosurg
Pays: India
ID NLM: 101564712
Informations de publication
Date de publication:
Historique:
received:
31
10
2019
revised:
16
02
2020
accepted:
23
11
2020
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Electrolyte imbalance and acute diabetes insipidus (DI) are the most common complications in patients undergoing craniopharyngioma excision. Data are sparse regarding the choice of fluid in these patients. We compared the effects of balanced salt solution and 0.45% saline infused perioperatively on serum osmolality and serum sodium levels in these patients. A prospective randomized double-blinded study was conducted in 30 patients undergoing transcranial excision of craniopharyngioma. The patients received either balanced salt solution or 0.45% sodium chloride solution perioperatively till they were allowed orally. Serum and urine osmolality, serum and urine sodium, urine specific gravity, and total dose of desmopressin required to treat DI were measured in the perioperative period. Demographic data were comparable. We observed that there was significantly higher serum osmolality in the intraoperative period at 2 0.45% sodium chloride solution has better effect on serum osmolality than balanced salt solution in patients undergoing transcranial resection of craniopharyngioma.
Sections du résumé
BACKGROUND
BACKGROUND
Electrolyte imbalance and acute diabetes insipidus (DI) are the most common complications in patients undergoing craniopharyngioma excision. Data are sparse regarding the choice of fluid in these patients. We compared the effects of balanced salt solution and 0.45% saline infused perioperatively on serum osmolality and serum sodium levels in these patients.
METHODOLOGY
METHODS
A prospective randomized double-blinded study was conducted in 30 patients undergoing transcranial excision of craniopharyngioma. The patients received either balanced salt solution or 0.45% sodium chloride solution perioperatively till they were allowed orally. Serum and urine osmolality, serum and urine sodium, urine specific gravity, and total dose of desmopressin required to treat DI were measured in the perioperative period.
RESULTS
RESULTS
Demographic data were comparable. We observed that there was significantly higher serum osmolality in the intraoperative period at 2
CONCLUSION
CONCLUSIONS
0.45% sodium chloride solution has better effect on serum osmolality than balanced salt solution in patients undergoing transcranial resection of craniopharyngioma.
Identifiants
pubmed: 34211879
doi: 10.4103/ajns.AJNS_324_19
pii: AJNS-16-126
pmc: PMC8202359
doi:
Types de publication
Journal Article
Langues
eng
Pagination
126-131Informations de copyright
Copyright: © 2021 Asian Journal of Neurosurgery.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Neurochirurgia (Stuttg). 1987 Sep;30(5):135-8
pubmed: 3683699
Surg Clin North Am. 1968 Aug;48(4):707-21
pubmed: 4877854
Neurol India. 2015 Sep-Oct;63(5):712-7
pubmed: 26448230
J Pediatr Endocrinol Metab. 2006 Apr;19 Suppl 1:413-21
pubmed: 16700319
Ann Surg. 1969 Nov;170(5):813-23
pubmed: 5347558
Childs Nerv Syst. 1998 Jun;14(6):276-9
pubmed: 9694340
Anesthesiol Clin North Am. 2002 Jun;20(2):329-46, vi
pubmed: 12165997
Anesth Analg. 1999 May;88(5):999-1003
pubmed: 10320158
Surg Neurol Int. 2014 Jul 08;5:105
pubmed: 25101200