Natural Killer Cell Dysfunction in Obese Patients with Breast Cancer: A Review of a Triad and Its Implications.
Adipokines
/ metabolism
Adipose Tissue
/ metabolism
Animals
Breast Neoplasms
/ complications
Cytokines
/ metabolism
Disease Models, Animal
Female
Humans
Immunity, Innate
Immunotherapy
/ methods
Killer Cells, Natural
/ immunology
Leptin
/ metabolism
Lymphocyte Activation
Obesity
/ complications
Resistin
/ metabolism
Tumor Microenvironment
/ immunology
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
03
2021
revised:
04
05
2021
accepted:
19
05
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
16
12
2021
Statut:
epublish
Résumé
Natural killer cells (NK cells) are a crucial constituent of the innate immune system as they mediate immunity against viruses, bacteria, parasites, and most importantly, tumor cells. The exact mechanism of how the innate immune system and specifically NK cells interact with cancer cells is complex and is yet to be understood. Several factors that constitute the tumor microenvironment (TME) such as hypoxia and TGF-
Identifiants
pubmed: 34212054
doi: 10.1155/2021/9972927
pmc: PMC8205589
doi:
Substances chimiques
Adipokines
0
Cytokines
0
Leptin
0
Resistin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9972927Informations de copyright
Copyright © 2021 Esraa Elaraby et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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