A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F

F2-isoprostanes interleukin-6 obesity older adults visceral adipose tissue

Journal

Current developments in nutrition
ISSN: 2475-2991
Titre abrégé: Curr Dev Nutr
Pays: United States
ID NLM: 101717957

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 31 03 2021
revised: 12 05 2021
accepted: 14 05 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Short-term markers of successful visceral adipose tissue (VAT) loss are needed. Urinary F This pilot study was designed to explore the hypotheses that Eighteen participants (aged 60-75 y, BMI 30-40 kg/m Within the VLCD group, change in VAT was inversely associated with change in IL-6 ( Results from this exploratory study in older adults with obesity suggest that, in the context of a VLCD, IL-6 could be involved in VAT mobilization, and urinary F

Sections du résumé

BACKGROUND BACKGROUND
Short-term markers of successful visceral adipose tissue (VAT) loss are needed. Urinary F
OBJECTIVES OBJECTIVE
This pilot study was designed to explore the hypotheses that
METHODS METHODS
Eighteen participants (aged 60-75 y, BMI 30-40 kg/m
RESULTS RESULTS
Within the VLCD group, change in VAT was inversely associated with change in IL-6 (
CONCLUSIONS CONCLUSIONS
Results from this exploratory study in older adults with obesity suggest that, in the context of a VLCD, IL-6 could be involved in VAT mobilization, and urinary F

Identifiants

pubmed: 34212125
doi: 10.1093/cdn/nzab082
pii: nzab082
pmc: PMC8238660
doi:

Banques de données

ClinicalTrials.gov
['NCT02760641']

Types de publication

Journal Article

Langues

eng

Pagination

nzab082

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK056336
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

Références

BMC Geriatr. 2019 Jul 3;19(1):183
pubmed: 31269909
J Zhejiang Univ Sci B. 2015 May;16(5):404-11
pubmed: 25990058
Cell Death Dis. 2019 Nov 18;10(12):870
pubmed: 31740668
Obesity (Silver Spring). 2012 Sep;20(9):1915-21
pubmed: 21959342
Circulation. 2007 Jul 3;116(1):39-48
pubmed: 17576866
Int J Obes (Lond). 2012 Sep;36(9):1141-50
pubmed: 22410960
J Nutr. 2015 Jan;145(1):177S-83S
pubmed: 25527677
J Clin Endocrinol Metab. 2005 Jan;90(1):316-22
pubmed: 15507518
Br J Nutr. 2018 Feb;119(3):259-270
pubmed: 29335039
Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1506-10
pubmed: 20501773
J Immunol. 2011 Dec 15;187(12):6208-16
pubmed: 22075699
Nutrients. 2018 Dec 02;10(12):
pubmed: 30513818
Cell Metab. 2015 Feb 3;21(2):237-248
pubmed: 25651178
J Endocr Soc. 2017 Apr 25;1(6):625-637
pubmed: 29264516
Am J Physiol Regul Integr Comp Physiol. 2014 Jun 1;306(11):R861-7
pubmed: 24694381
Clin Chim Acta. 2012 Oct 9;413(19-20):1446-53
pubmed: 22683781
Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E832-40
pubmed: 20823453
Nutrients. 2018 Nov 07;10(11):
pubmed: 30405021
Health Aff (Millwood). 2005;24 Suppl 2:W5R30-41
pubmed: 16186149
Cell Metab. 2018 Apr 3;27(4):805-815.e4
pubmed: 29576535
Circulation. 2007 Sep 11;116(11):1234-41
pubmed: 17709633
Eur J Pediatr. 2010 Aug;169(8):965-70
pubmed: 20169448
Aging Cell. 2018 Apr;17(2):
pubmed: 29424490
Obes Res. 2005 Sep;13(9):1638-44
pubmed: 16222068
Biochem Biophys Res Commun. 2004 Jul 23;320(2):449-54
pubmed: 15219849
Nutr Metab (Lond). 2020 Aug 12;17:64
pubmed: 32817749
Am J Physiol Endocrinol Metab. 2017 Mar 1;312(3):E204-E214
pubmed: 28028037
Nat Med. 2011 Oct 30;17(11):1481-9
pubmed: 22037645
Immunol Cell Biol. 2014 Apr;92(4):331-9
pubmed: 24751614
J Gerontol A Biol Sci Med Sci. 2017 Apr 1;72(4):513-519
pubmed: 27567109
Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E155-62
pubmed: 15383370
Diabetes Care. 2012 Jan;35(1):173-4
pubmed: 22100959
Pflugers Arch. 2020 Feb;472(2):217-233
pubmed: 31781893
Obesity (Silver Spring). 2013 Jun;21(6):1139-42
pubmed: 23671029
Exp Physiol. 2012 Nov;97(11):1224-35
pubmed: 22523382
Biomarkers. 2005 Nov;10 Suppl 1:S10-23
pubmed: 16298907
Int J Exerc Sci. 2020 May 01;13(3):802-817
pubmed: 32509120
Diabetes Care. 1999 Sep;22(9):1471-8
pubmed: 10480511
Free Radic Biol Med. 2005 Mar 15;38(6):698-710
pubmed: 15721980
Antioxid Redox Signal. 2008 Aug;10(8):1405-34
pubmed: 18522490
Obesity (Silver Spring). 2011 Apr;19(4):861-7
pubmed: 20948516
Eur J Clin Nutr. 2000 Jun;54 Suppl 3:S48-53
pubmed: 11041075
Oxid Med Cell Longev. 2015;2015:729191
pubmed: 25802683
Oxid Med Cell Longev. 2017;2017:8319176
pubmed: 28250893
Physiology (Bethesda). 2017 Jan;32(1):9-19
pubmed: 27927801
Nat Med. 2002 Jan;8(1):75-9
pubmed: 11786910
J Clin Endocrinol Metab. 2003 Jul;88(7):3005-10
pubmed: 12843134
Ageing Res Rev. 2017 May;35:200-221
pubmed: 27702700
Toxicol Lett. 2020 Aug 1;328:19-27
pubmed: 32320775
J Dairy Sci. 2014;97(6):3441-8
pubmed: 24704230
PLoS One. 2017 Dec 18;12(12):e0189301
pubmed: 29253016
Geriatr Gerontol Int. 2014 Feb;14 Suppl 1:8-14
pubmed: 24450556
Cell Metab. 2019 Apr 2;29(4):844-855.e3
pubmed: 30595477
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9383-7
pubmed: 2123555

Auteurs

Sarah E Hoover (SE)

Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.

Dora Il'yasova (D)

MTX Group, Inc., Albany, New York, NY, USA.

Kevin R Fontaine (KR)

Department of Health Behavior, University of Alabama at Birmingham, Birmingham, AL, USA.

Ivan Spasojevic (I)

Duke University School of Medicine, Durham, NC, USA.

Barbara A Gower (BA)

Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.

Amy M Goss (AM)

Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.

Classifications MeSH