Altered brain structural topological properties and its correlations with clinical characteristics in episodic migraine without aura.
Brain connectome
Diffusion tensor imaging
Graph theory
Network topology
Structural MRI
Journal
Neuroradiology
ISSN: 1432-1920
Titre abrégé: Neuroradiology
Pays: Germany
ID NLM: 1302751
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
24
01
2021
accepted:
08
04
2021
pubmed:
3
7
2021
medline:
17
11
2021
entrez:
2
7
2021
Statut:
ppublish
Résumé
To investigate the topological alterations of the whole-brain white matter structural networks in episodic migraine (EM) without aura. Forty-five EM patients without aura and 35 age- and sex-matched healthy controls were registered, and underwent diffusion tensor MRI acquisition at interictal. Graph theory-based analyses were then performed for the characterization of brain structural network properties. Pearson correlation analysis was performed on each network metric between the EM patients and healthy controls. The EM patients exhibited abnormal global network properties and local network topology that were characterized by more strongly integrated, more efficient, and faster information transferring. These network differences were widely located in the occipital, temporal, and parietal regions. Additionally, the local efficient of global parameters showed positive correlation with visual analogue scale, and along with prolonging disease duration, the nodal efficiency would be reduced, and the nodal shortest path length would be increased. Headache Impact Test version 6 scores have negative correlation with the nodal shortest path length, and positive correlations with the nodal efficiency. The results indicate that EM patients had aberrant topological structure and make a better understanding of structural connectivity in EM; it may provide imaging evidence for clinical study of migraine pathogenesis.
Identifiants
pubmed: 34212221
doi: 10.1007/s00234-021-02716-9
pii: 10.1007/s00234-021-02716-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2099-2109Subventions
Organisme : Medicine Scientific key Research Project of Chongqing Municipal Health and Family Planning Commission
ID : 2016ZDXM002
Organisme : the Chongqing basic research and frontier exploration project of Chongqing Science &Technology Commission
ID : cstc2018jcyjAX0584
Organisme : the National Key Research&Development Plan of Ministry of Science and Technology of the People's Republic of China
ID : 2016YFC0107109
Organisme : Medical Scientific Youth Project of Chongqing Municipal Health and Family Planning Commission of China
ID : 2018QNXM004
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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