Increased Levels of serum Pentraxin 3 in Critical Coronavirus Disease-2019 Patients.
COVID-19
Coronavirus
Ficolin
Pattern recognition receptors
Pentraxin 3
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
20
05
2021
accepted:
24
06
2021
pubmed:
3
7
2021
medline:
22
11
2022
entrez:
2
7
2021
Statut:
ppublish
Résumé
Pentraxin 3 (PTX3) and ficolin are the plasma phase of pattern recognition receptors (PRRs) and can activate complement through classical and lectin pathways, respectively, which may contribute to disease severity. This study aimed to investigate the association between PTX3 and ficolin with disease severity in patients with coronavirus disease-2019 (COVID-19). Seventy-three COVID-19 patients and 25 healthy controls were enrolled in this study. The participants were divided into three groups as follows: 14 patients as the intensive care unit (ICU) group, 59 patients as the non-ICU group, and 25 subjects as the healthy control group. The serum levels of PTX3 and ficolin were measured by enzyme-linked immunosorbent assay (ELISA) kits. Patients in ICU and non-ICU groups had significantly higher levels of PTX3 compared to the healthy control group (p = 0.0002 and p = 0.0072, respectively). Patients in the ICU group also had an increased amount of PTX3 (1957 ± 1769 pg/ml) compared to non-ICU patients (1220 ± 1784 pg/ml). However, this difference was not significant. On the other hand, serum levels of ficolin were not different among the three groups. PTX3, as an acute phase protein, may contribute to disease severity. Its probable inflammatory role could result from the high activation of the complement system. On the other hand, it could be suggested that ficolin has no crucial role in the disease severity of COVID-19 patients.
Identifiants
pubmed: 34212320
doi: 10.1007/s11356-021-15183-9
pii: 10.1007/s11356-021-15183-9
pmc: PMC8248285
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
PTX3 protein
148591-49-5
Serum Amyloid P-Component
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
85569-85573Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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