Hierarchical distribution of somatic variants in newly diagnosed chronic myeloid leukaemia at diagnosis and early follow-up.
ASXL1
CML
NGS
leukaemic stem cells
progenitors
somatic mutations
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
28
05
2021
received:
03
02
2021
accepted:
01
06
2021
pubmed:
3
7
2021
medline:
15
12
2021
entrez:
2
7
2021
Statut:
ppublish
Résumé
There is an emerging body of evidence that patients with chronic myeloid leukaemia (CML) may carry not only breakpoint cluster region-Abelson murine leukaemia viral oncogene homologue 1 (BCR-ABL1) kinase domain mutations (BCR-ABL1 KD mutations), but also mutations in other genes. Their occurrence is highest during progression or at failure, but their impact at diagnosis is unclear. In the present study, we prospectively screened for mutations in 18 myeloid neoplasm-associated genes and BCR-ABL1 KD in the following populations: bulk leucocytes, CD34
Substances chimiques
BCR-ABL1 fusion protein, human
0
Fusion Proteins, bcr-abl
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
604-612Informations de copyright
© 2021 British Society for Haematology and John Wiley & Sons Ltd.
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