The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice.

Animals Circadian Rhythm / physiology Eye Proteins / genetics Female Fertility / physiology Homeodomain Proteins / genetics Male Mice Mice, Inbred C57BL Mice, Transgenic NIH 3T3 Cells Nerve Tissue Proteins / genetics Neuropeptides / genetics Running / physiology Suprachiasmatic Nucleus / metabolism Homeobox Protein SIX3
PER2::luciferase circadian conditional knock-out luteinizing hormone surge six homeobox 3 ventral anterior homeobox 1

Journal

Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111

Informations de publication

Date de publication:
10 2021
Historique:
received: 30 10 2020
accepted: 10 05 2021
pubmed: 3 7 2021
medline: 11 2 2022
entrez: 2 7 2021
Statut: ppublish

Résumé

The homeodomain transcription factors sine oculis homeobox 3 (Six3) and ventral anterior homeobox 1 (Vax1) are required for brain development. Their expression in specific brain areas is maintained in adulthood, where their functions are poorly understood. To identify the roles of Six3 and Vax1 in neurons, we conditionally deleted each gene using Synapsin

Identifiants

DOI: 10.1002/jnr.24864 PMID: 34212416 PMC: PMC8577618
pubmed: 34212416
doi: 10.1002/jnr.24864
pmc: PMC8577618
mid: NIHMS1747796
doi:

Substances chimiques

Eye Proteins 0
Homeodomain Proteins 0
Nerve Tissue Proteins 0
Neuropeptides 0
Vax1 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2625-2645

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD100580
Pays : United States
Organisme : NICHD NIH HHS
ID : R00 HD084759
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD087166
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES010337
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD028934
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023100
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK044838
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072754
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD082567
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007203
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS047101
Pays : United States
Organisme : BLRD VA
ID : I01 BX001146
Pays : United States
Organisme : NICHD NIH HHS
ID : K99 HD084759
Pays : United States
Organisme : NICHD NIH HHS
ID : F32 HD090837
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD012303
Pays : United States
Organisme : NICHD NIH HHS
ID : R24 HD102061
Pays : United States

Informations de copyright

© 2021 Wiley Periodicals, LLC.

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Auteurs

Hanne M Hoffmann (HM)

Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.
Department of Animal Science and the Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, MI, USA.
ORCID: 0000-0003-1555-1369

Jason D Meadows (JD)

Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.

Joseph A Breuer (JA)

Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.

Alexandra M Yaw (AM)

Department of Animal Science and the Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, MI, USA.
ORCID: 0000-0003-4415-4450

Duong Nguyen (D)

Department of Animal Science and the Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, MI, USA.

Karen J Tonsfeldt (KJ)

Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0001-8044-8857

Austin Y Chin (AY)

Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.

Brooke M Devries (BM)

Department of Animal Science and the Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, MI, USA.

Crystal Trang (C)

Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.

Haley J Oosterhouse (HJ)

Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.

Jessica Sora Lee (JS)

Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.

Jeffrey W Doser (JW)

CANR Statistical Consulting Center, Michigan State University, East Lansing, MI, USA.
ORCID: 0000-0002-8950-9895

Michael R Gorman (MR)

Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.
Department of Psychology, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0001-6122-8437

David K Welsh (DK)

Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
ORCID: 0000-0001-9121-3164

Pamela L Mellon (PL)

Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-8856-0410

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Rythme circadien › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de l'oeil › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Fécondité › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Cellules NIH 3T3 › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Activités humaines › Activités de loisirs › Loisir › Sports › Course à pied › The transcription factors SIX3 and VAX1 are...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Hypothalamus antérieur › Noyau suprachiasmatique › The transcription factors SIX3 and VAX1 are...