SUMO wrestling in the cellular dohyō: crosstalk between phosphorylation and SUMOylation of PKCδ regulates oxidative cell damage.
Caspase-3
PKCδ
SUMOylation
apoptosis
oxidative stress
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
14
05
2021
accepted:
19
05
2021
pubmed:
3
7
2021
medline:
30
11
2021
entrez:
2
7
2021
Statut:
ppublish
Résumé
The novel PKCδ isoform has been shown to mediate a pro-apoptotic function in response to oxidative stressors. Siman Gao and colleagues performed an in-depth biochemical and molecular analysis of factors that regulate PKCδ function. They demonstrated convincingly that PKCδ is regulated by an interplay between SUMOylation and phosphorylation. They also showed that these events are critical for hydrogen peroxide induced apoptosis, thus identifying potentially novel mechanisms that may be harnessed for cell protection. Comment on: https://doi.org/10.1111/febs.16050.
Substances chimiques
Hydrogen Peroxide
BBX060AN9V
Protein Kinase C-delta
EC 2.7.11.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6406-6409Informations de copyright
© 2021 Federation of European Biochemical Societies.
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