Antioxidant Effects of Elderberry Anthocyanins in Human Colon Carcinoma Cells: A Study on Structure-Activity Relationships.
anthocyanin
cyanidin
elderberry
oxidative stress
phloroglucinol aldehyde
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
09
06
2021
received:
11
03
2021
pubmed:
3
7
2021
medline:
2
2
2022
entrez:
2
7
2021
Statut:
ppublish
Résumé
Glycosylation is a way to increase structure-stability of anthocyanins, yet compromises their bioactivity. The study investigates the antioxidant activity of purified cyanidin (Cy)-based anthocyanins and respective degradation products in Caco-2 clone C2BBe1 aiming to identify structure-activity relationships. Cyanidin 3-O-glucoside (Cy-3-glc) and cyanidin 3-O-sambubioside (Cy-3-sam) proved to be most potent regarding antioxidant properties and protection against hydrogen peroxide (H More complex residues and numbers of sugar moieties appear to be counterproductive for antioxidant activity. Other mechanisms than Nrf2-activation should be considered for protective effects.
Identifiants
pubmed: 34212508
doi: 10.1002/mnfr.202100229
pmc: PMC8459241
doi:
Substances chimiques
Anthocyanins
0
Antioxidants
0
Enzymes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100229Informations de copyright
© 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
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