Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria.
Chronic urticaria
autoantibodies
autoimmune diseases
autoimmune thyroiditis
autoimmunity
immunoassay
omalizumab
vitiligo
Journal
Allergy, asthma & immunology research
ISSN: 2092-7355
Titre abrégé: Allergy Asthma Immunol Res
Pays: Korea (South)
ID NLM: 101518382
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
16
09
2020
revised:
10
11
2020
accepted:
23
11
2020
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
ppublish
Résumé
Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases. We analyzed records of CSU patients (n = 1,199) for a history or presence of autoimmune diseases. Patients were diagnosed with type IIb autoimmune CSU (aiCSU) if all 3 tests were positive: autologous serum skin test (ASST), basophil histamine release assay (BHRA) and/or basophil activation test (BAT), and IgG autoantibodies against FcεRIα/IgE detected by immunoassay. Twenty-eight percent of CSU patients had at least 1 autoimmune disease. The most prevalent autoimmune diseases were Hashimoto's thyroiditis (HT) (≥ 21%) and vitiligo (2%). Two percent of CSU patients had ≥ 2 autoimmune diseases, most frequently HT plus vitiligo. Comorbid autoimmune diseases, in patients with CSU, were associated with female sex, a family history of autoimmune diseases, and higher rates of hypothyroidism and hyperthyroidism ( In CSU, autoimmune diseases are common and linked to type IIb autoimmune CSU. Our results suggest that physicians assess and monitor all adult patients with CSU for signs and symptoms of common autoimmune diseases, especially HT and vitiligo.
Identifiants
pubmed: 34212543
pii: 13.545
doi: 10.4168/aair.2021.13.4.545
pmc: PMC8255350
doi:
Types de publication
Journal Article
Langues
eng
Pagination
545-559Subventions
Organisme : GA²LEN
Informations de copyright
Copyright © 2021 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.
Déclaration de conflit d'intérêts
Pavel Kolkhir: is or recently was a speaker for Novartis and Roche. No relevant conflicts of interest in relation to this work.
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