Exposure to Polyhexamethylene Guanidine Exacerbates Bronchial Hyperresponsiveness and Lung Inflammation in a Mouse Model of Ovalbumin-Induced Asthma.
Humidifiers
Serpins
asthma
bronchial hyperreactivity
chemokine CCL11
disinfectants
mice
polyhexamethyleneguanidine
Journal
Allergy, asthma & immunology research
ISSN: 2092-7355
Titre abrégé: Allergy Asthma Immunol Res
Pays: Korea (South)
ID NLM: 101518382
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
15
07
2020
revised:
22
11
2020
accepted:
26
11
2020
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
ppublish
Résumé
Humidifier disinfectants (HDs) exposure has now been associated with acute lung injury and pulmonary fibrosis; polyhexamethylene guanidine (PHMG) has been confirmed to cause severe lung inflammation and fibrosis in mice. Recent evidence also indicates that HDs exposure increases the asthma risk in children, but the underlying mechanisms remain unclear. We aimed to investigate the effects of PHMG exposure on asthma in mice and the potential underlying mechanisms. BALB/c mice were intranasally administered PHMG (0.1 mg/kg/day; 5 days per week) during 2 episodes of ovalbumin (OVA) sensitization and were then challenged with 1% OVA by inhalation. Bronchial hyperresponsiveness (BHR), inflammatory cell influx into bronchoalveolar lavage (BAL) fluid, serum total and OVA-specific immunoglobulin (Ig) E levels, and histopathological changes in the lung were analyzed. The levels of asthma-related cytokines and chemokines were assayed in the lung tissues to evaluate possible mechanisms. Exposure to PHMG following OVA sensitization and challenge significantly enhanced BHR, inflammatory cell counts in BAL fluid, airway inflammation, and total serum IgE levels in the asthma mouse model. In addition, the levels of
Identifiants
pubmed: 34212551
pii: 13.655
doi: 10.4168/aair.2021.13.4.655
pmc: PMC8255342
doi:
Types de publication
Journal Article
Langues
eng
Pagination
655-664Subventions
Organisme : Ministry of Environment
ID : NIER-SP2020-007
Pays : Korea
Informations de copyright
Copyright © 2021 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.
Déclaration de conflit d'intérêts
There are no financial or other issues that might lead to conflict of interest.
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