Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering.
cell cycle duration
computational biology
computational model
developmental biology
early development
eukaryotes
fate decisions
none
systems biology
transcriptional filter
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 07 2021
02 07 2021
Historique:
received:
17
11
2020
accepted:
01
07
2021
pubmed:
3
7
2021
medline:
21
10
2021
entrez:
2
7
2021
Statut:
epublish
Résumé
Cell cycle duration changes dramatically during development, starting out fast to generate cells quickly and slowing down over time as the organism matures. The cell cycle can also act as a transcriptional filter to control the expression of long gene transcripts, which are partially transcribed in short cycles. Using mathematical simulations of cell proliferation, we identify an emergent property that this filter can act as a tuning knob to control gene transcript expression, cell diversity, and the number and proportion of different cell types in a tissue. Our predictions are supported by comparison to single-cell RNA-seq data captured over embryonic development. Additionally, evolutionary genome analysis shows that fast-developing organisms have a narrow genomic distribution of gene lengths while slower developers have an expanded number of long genes. Our results support the idea that cell cycle dynamics may be important across multicellular animals for controlling gene transcript expression and cell fate.
Identifiants
pubmed: 34212855
doi: 10.7554/eLife.64951
pii: 64951
pmc: PMC8279763
doi:
pii:
Banques de données
GEO
['GSE107122', 'GSE113074', 'GSE112294', 'GSE134707']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Abou Chakra et al.
Déclaration de conflit d'intérêts
MA, RI, TT, GB No competing interests declared
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