eIF4A inhibitors PatA and RocA stack the deck against translation.

Eukaryotic Initiation Factor-4A / genetics Humans Protein Biosynthesis RNA / metabolism

Journal

Structure (London, England : 1993)
ISSN: 1878-4186
Titre abrégé: Structure
Pays: United States
ID NLM: 101087697

Informations de publication

Date de publication:
01 07 2021
Historique:
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 24 8 2021
Statut: ppublish

Résumé

In Cell Chemical Biology, Naineni et al. (2021) report the structure of a synthetic analog of the translation inhibitor pateamine A bound to initiation factor eIF4A and RNA. The drug stacks with RNA bases in the same pocket where unrelated rocaglate compounds bind, highlighting a druggable site for DEAD-box proteins.

Identifiants

DOI: 10.1016/j.str.2021.06.009 PMID: 34214439
pubmed: 34214439
pii: S0969-2126(21)00213-6
doi: 10.1016/j.str.2021.06.009
pii:
doi:

Substances chimiques

RNA 63231-63-0
Eukaryotic Initiation Factor-4A EC 2.7.7.-

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

638-639

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The author declares no competing interests.

Auteurs

Nicholas T Ingolia (NT)

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: ingolia@berkeley.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines ribosomiques › Facteurs initiation chaîne peptidique › Facteurs d'initiation eucaryotes › Facteur-4F d'initiation eucaryote › Facteur-4A d'initiation eucaryote › eIF4A inhibitors PatA and RocA stack the deck...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › eIF4A inhibitors PatA and RocA stack the deck...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › eIF4A inhibitors PatA and RocA stack the deck...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › eIF4A inhibitors PatA and RocA stack the deck...