Mechanisms of organelle elimination for lens development and differentiation.
Autophagy
Chromatin
Development
Differentiation
Endoplasmic reticulum
Golgi apparatus
Hypoxia
Lens
Mitochondria
Nucleus
Organelle regulation
Transcriptional regulation
Journal
Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
29
03
2021
revised:
03
06
2021
accepted:
19
06
2021
pubmed:
3
7
2021
medline:
1
12
2021
entrez:
2
7
2021
Statut:
ppublish
Résumé
A hallmark feature of lens development and differentiation is the complete elimination of organelles from the center of the eye lens. A long unanswered question in lens biology is what are the mechanisms that control the elimination of organelles during the terminal remodeling program to form mature lens fiber cells? Recent advances have expanded our understanding of these mechanisms including newly discovered signaling pathways, proteasomal regulators, autophagy proteins, transcription factors and the hypoxic environment of the lens itself. These recent discoveries suggest that distinct mechanisms coordinate the elimination of the nucleus, mitochondria, endoplasmic reticulum and Golgi apparatus during lens fiber cell differentiation. Since regulation of organelle number and distribution is also a feature of the terminal remodeling programs of more complex cell-types and tissues, these advances are likely to impact a wide-variety of fields.
Identifiants
pubmed: 34214522
pii: S0014-4835(21)00248-7
doi: 10.1016/j.exer.2021.108682
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108682Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.