Unusual matrine-adenine hybrids isolated from Sophora davidii and their inhibitory effects on human cytomegalovirus.
Alkaloids
Anti- human cytomegalovirus
Edible flowers
Fabaceae
Matrine–adenine hybrids
Sophora davidii
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
05
03
2021
revised:
09
06
2021
accepted:
10
06
2021
pubmed:
3
7
2021
medline:
25
8
2021
entrez:
2
7
2021
Statut:
ppublish
Résumé
A phytochemical investigation on the flowers of Sophora davidii resulted in the isolation of three unusual matrine-adenine hybrids, sophovicines A-C, together with biogenetically related analogue sophocarpine. Their structures and absolute configurations were determined by NMR analysis, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) data. Since sophovicines represent the first example of matrine-adenine hybrids, a putative biosynthetic pathway toward sophovicines A-C was proposed. In addition, computational molecular modeling suggested that compounds sophovicines B and C may have potent activities against human cytomegalovirus (HCMV). So, the inhibit effects of isolates on HCMV were evaluated. The results show that sophovicines B and C can inhibit HCMV replication effectively with IC
Identifiants
pubmed: 34214924
pii: S0031-9422(21)00191-6
doi: 10.1016/j.phytochem.2021.112842
pii:
doi:
Substances chimiques
Alkaloids
0
Quinolizines
0
Adenine
JAC85A2161
Matrines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112842Informations de copyright
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