Interaction of developmental factors and ordinary stressful life events on brain structure in adults.
Magnetic resonance imaging
Orbitofrontal cortex
Stressful life events
Voxel-based morphometry
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
01
2021
revised:
15
04
2021
accepted:
17
04
2021
entrez:
3
7
2021
pubmed:
4
7
2021
medline:
31
7
2021
Statut:
ppublish
Résumé
An interplay of early environmental and genetic risk factors with recent stressful life events (SLEs) in adulthood increases the risk for adverse mental health outcomes. The interaction of early risk and current SLEs on brain structure has hardly been investigated. Whole brain voxel-based morphometry analysis was performed in N = 786 (64.6% female, mean age = 33.39) healthy subjects to identify correlations of brain clusters with commonplace recent SLEs. Genetic and early environmental risk factors, operationalized as those for severe psychopathology (i.e., polygenic scores for neuroticism, childhood maltreatment, urban upbringing and paternal age) were assessed as modulators of the impact of SLEs on the brain. SLEs were negatively correlated with grey matter volume in the left medial orbitofrontal cortex (mOFC, FWE p = 0.003). This association was present for both, positive and negative, life events. Cognitive-emotional variables, i.e., neuroticism, perceived stress, trait anxiety, intelligence, and current depressive symptoms did not account for the SLE-mOFC association. Further, genetic and environmental risk factors were not correlated with grey matter volume in the left mOFC cluster and did not affect the association between SLEs and left mOFC grey matter volume. The orbitofrontal cortex has been implicated in stress-related psychopathology, particularly major depression in previous studies. We find that SLEs are associated with this area. Important early life risk factors do not interact with current SLEs on brain morphology in healthy subjects.
Identifiants
pubmed: 34215153
pii: S2213-1582(21)00127-3
doi: 10.1016/j.nicl.2021.102683
pmc: PMC8102615
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102683Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
Références
Neurosci Biobehav Rev. 2008;32(3):525-49
pubmed: 18061263
J Psychiatr Res. 2018 Aug;103:189-207
pubmed: 29886003
Mol Psychiatry. 2021 Apr;26(4):1286-1298
pubmed: 31712721
PLoS Genet. 2009 Jun;5(6):e1000529
pubmed: 19543373
Biol Psychiatry. 2012 Jul 1;72(1):57-64
pubmed: 22218286
Clin EEG Neurosci. 2020 Jul;51(4):275-284
pubmed: 32028799
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10;88:287-302
pubmed: 30118825
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
Schizophr Bull. 2011 Sep;37(5):1039-47
pubmed: 20185538
J Affect Disord. 2012 Dec 20;143(1-3):196-202
pubmed: 22884233
Nat Methods. 2013 Jan;10(1):5-6
pubmed: 23269371
J Neurosci Res. 2021 Mar 31;:
pubmed: 33789356
Cereb Cortex. 2006 Dec;16(12):1809-19
pubmed: 16421327
Stress Health. 2012 Apr;28(2):102-10
pubmed: 22281953
Psychother Psychosom Med Psychol. 2010 Nov;60(11):442-50
pubmed: 20200804
Neuroimage. 2004 Sep;23(1):84-97
pubmed: 15325355
Stress. 2011 Mar;14(2):227-32
pubmed: 21034297
Nat Genet. 2012 Jul 22;44(8):955-9
pubmed: 22820512
Front Syst Neurosci. 2017 Apr 27;11:25
pubmed: 28496402
Neuropsychobiology. 2020;79(4-5):270-283
pubmed: 31340207
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Mol Autism. 2020 Jun 23;11(1):54
pubmed: 32576230
J Health Soc Behav. 1983 Dec;24(4):385-96
pubmed: 6668417
Neuropsychopharmacology. 2014 Feb;39(3):670-80
pubmed: 24051900
Annu Rev Psychol. 2019 Jan 4;70:577-597
pubmed: 29949726
Neuroimage. 2014 May 15;92:1-7
pubmed: 24495811
Eur Neuropsychopharmacol. 2012 Jan;22(1):1-16
pubmed: 21723712
Neuroimage. 2018 May 15;172:450-460
pubmed: 29410079
Soc Cogn Affect Neurosci. 2016 Apr;11(4):537-47
pubmed: 26568620
Nature. 2011 Jun 22;474(7352):498-501
pubmed: 21697947
World Psychiatry. 2017 Jun;16(2):121-129
pubmed: 28498595
Nat Genet. 2018 Jan;50(1):6-11
pubmed: 29255261
Neurosci Biobehav Rev. 2014 Nov;47:260-80
pubmed: 25124509
Nat Commun. 2019 Apr 16;10(1):1776
pubmed: 30992449
IEEE Trans Med Imaging. 1997 Apr;16(2):176-86
pubmed: 9101327
Cereb Cortex. 2020 Jan 10;30(1):215-225
pubmed: 31329833
Annu Rev Clin Psychol. 2008;4:33-52
pubmed: 17716038
Eur Arch Psychiatry Clin Neurosci. 2019 Dec;269(8):949-962
pubmed: 30267149
Res Nurs Health. 1984 Mar;7(1):61-71
pubmed: 6565302
Physiol Rev. 2007 Jul;87(3):873-904
pubmed: 17615391
Neuroimage. 2005 Jul 1;26(3):839-51
pubmed: 15955494
Mol Psychiatry. 2013 May;18(5):618-23
pubmed: 22614289
Front Neurosci. 2012 Nov 01;6:157
pubmed: 23125822