Observation of charged droplets from electrospray ionization (ESI) plumes in API mass spectrometers.
Charged droplets detection
Droplet aspiration
Electrospray ionization
Instrument contamination
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
02
02
2021
accepted:
02
06
2021
revised:
11
05
2021
pubmed:
4
7
2021
medline:
4
7
2021
entrez:
3
7
2021
Statut:
ppublish
Résumé
Electrospray ionization (ESI) generates bare analyte ions from charged droplets, which result from spraying a liquid in a strong electric field. Experimental observations available in the literature suggest that at least a significant fraction of the initially generated droplets remain large, have long lifetimes, and can thus aspirate into the inlet system of an atmospheric pressure ionization mass spectrometer (API-MS). We report on the observation of fragment signatures from charged droplets penetrating deeply the vacuum stages of three commercial mass spectrometer systems with largely different ion source and spray configurations. Charged droplets can pass through the ion source and pressure reduction stages and even into the mass analyzer region. Since droplet signatures were found in all investigated instruments, the incorporation of charged droplets is considered a general phenomenon occurring with common spray conditions in ESI sources.
Identifiants
pubmed: 34215914
doi: 10.1007/s00216-021-03452-y
pii: 10.1007/s00216-021-03452-y
pmc: PMC8410725
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5587-5600Informations de copyright
© 2021. The Author(s).
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