The key amino acids of E protein involved in early flavivirus infection: viral entry.
Envelope protein
Flavivirus
Key amino acids
Viral attachment
Viral entry
Journal
Virology journal
ISSN: 1743-422X
Titre abrégé: Virol J
Pays: England
ID NLM: 101231645
Informations de publication
Date de publication:
03 07 2021
03 07 2021
Historique:
received:
07
04
2021
accepted:
29
06
2021
entrez:
4
7
2021
pubmed:
5
7
2021
medline:
23
2
2022
Statut:
epublish
Résumé
Flaviviruses are enveloped viruses that infect multiple hosts. Envelope proteins are the outermost proteins in the structure of flaviviruses and mediate viral infection. Studies indicate that flaviviruses mainly use envelope proteins to bind to cell attachment receptors and endocytic receptors for the entry step. Here, we present current findings regarding key envelope protein amino acids that participate in the flavivirus early infection process. Among these sites, most are located in special positions of the protein structure, such as the α-helix in the stem region and the hinge region between domains I and II, motifs that potentially affect the interaction between different domains. Some of these sites are located in positions involved in conformational changes in envelope proteins. In summary, we summarize and discuss the key envelope protein residues that affect the entry process of flaviviruses, including the process of their discovery and the mechanisms that affect early infection.
Identifiants
pubmed: 34217298
doi: 10.1186/s12985-021-01611-2
pii: 10.1186/s12985-021-01611-2
pmc: PMC8254458
doi:
Substances chimiques
Amino Acids
0
Viral Envelope Proteins
0
glycoprotein E, Flavivirus
145420-18-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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