Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage.
Da-cheng-qi decoction
Emodin
Intracerebral hemorrhage
NR2B/p38 signals pathway
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
30
01
2021
revised:
15
05
2021
accepted:
10
06
2021
pubmed:
5
7
2021
medline:
30
9
2021
entrez:
4
7
2021
Statut:
ppublish
Résumé
Intracerebral hemorrhage (ICH), the most fatal subtype of stroke, has no disease-modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used Chinese traditional decoctions in ICH treatment. But the mechanism is not clear. Emodin is an active compound found in rhubarb. To study the protective effects of DCQ on ICH and its possible mechanisms of action. The ICH model was reproduced by injecting collagenase-VII into the left caudate putamen (CPu) of rats. DCQ and emodin were used to treat the ICH rats for 7 days. Behavior tests, proteomic analysis, morphological studies, and western blotting were performed. The neurological deficits in the ICH rats recovered with DCQ and emodin on the 14 The protective effects of DCQ on ICH were confirmed in this study, and its mechanism may be related to the inhibition of MAPK and activation of M2 microglia. These results are beneficial to the development of ICH therapeutic targets.
Sections du résumé
BACKGROUND
BACKGROUND
Intracerebral hemorrhage (ICH), the most fatal subtype of stroke, has no disease-modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used Chinese traditional decoctions in ICH treatment. But the mechanism is not clear. Emodin is an active compound found in rhubarb.
PURPOSE
OBJECTIVE
To study the protective effects of DCQ on ICH and its possible mechanisms of action.
METHODS
METHODS
The ICH model was reproduced by injecting collagenase-VII into the left caudate putamen (CPu) of rats. DCQ and emodin were used to treat the ICH rats for 7 days. Behavior tests, proteomic analysis, morphological studies, and western blotting were performed.
RESULTS
RESULTS
The neurological deficits in the ICH rats recovered with DCQ and emodin on the 14
CONCLUSION
CONCLUSIONS
The protective effects of DCQ on ICH were confirmed in this study, and its mechanism may be related to the inhibition of MAPK and activation of M2 microglia. These results are beneficial to the development of ICH therapeutic targets.
Identifiants
pubmed: 34217968
pii: S0944-7113(21)00173-2
doi: 10.1016/j.phymed.2021.153630
pii:
doi:
Substances chimiques
Da-Cheng-Qi
0
Drugs, Chinese Herbal
0
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Emodin
KA46RNI6HN
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
153630Informations de copyright
Copyright © 2021. Published by Elsevier GmbH.