New cytotoxic dichapetalins in the leaves of Phyllanthus acidus: Identification, quantitative analysis, and preliminary toxicity assessment.
Antineoplastic Agents, Phytogenic
/ chemistry
Cell Line
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Phyllanthus
/ chemistry
Plant Extracts
/ chemistry
Plant Leaves
/ chemistry
Structure-Activity Relationship
Cytotoxicity
Dichapetalins
Euphorbiaceae
Pacidusins A-D
Phyllanthus acidus
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
26
10
2020
revised:
12
05
2021
accepted:
23
06
2021
pubmed:
5
7
2021
medline:
15
12
2021
entrez:
4
7
2021
Statut:
ppublish
Résumé
The young leaves of Phyllanthus acidus (Euphorbiaceae) are commonly used as edible vegetables in Indonesia, Thailand, and India, and their water infusions as dieting aids for people trying to remain slim. However, it is regarded as a poisonous plant in Malaya, and current researches are insufficient to provide a conclusion on its toxicity and safety under large doses. In this study, we firstly found that the refined nonpolar extracts of P. acidus leaves showed significant cytotoxic effect against BEAS-2B and L02 normal cell lines with IC
Identifiants
pubmed: 34217976
pii: S0045-2068(21)00502-2
doi: 10.1016/j.bioorg.2021.105125
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105125Informations de copyright
Copyright © 2021. Published by Elsevier Inc.