Determining prognostic variables of treatment outcome in obsessive-compulsive disorder: effectiveness and its predictors in routine clinical care.

Adult Female Humans Male Obsessive-Compulsive Disorder / therapy Prognosis Treatment Outcome
Effectiveness Obsessive–compulsive disorder Patient characteristics Predictors Prognostic variables

Journal

European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 27 11 2020
accepted: 14 06 2021
pubmed: 5 7 2021
medline: 15 3 2022
entrez: 4 7 2021
Statut: ppublish

Résumé

The objectives of this study were to investigate the naturalistic effectiveness of routine inpatient treatment for patients with obsessive-compulsive disorder (OCD) and to identify predictors of treatment outcome. A routinely collected data set of 1,596 OCD inpatients (M = 33.9 years, SD = 11.7; 60.4% female) having received evidence-based psychotherapy based on the cognitive-behavioral therapy (CBT) in five German psychotherapeutic clinics was analyzed. Effect sizes (Hedges' g) were calculated for several outcome variables to determine effectiveness. Predictor analyses were performed on a subsample (N = 514; M = 34.3 years, SD = 12.2; 60.3% female). For this purpose, the number of potential predictors was reduced using factor analysis, followed by multiple regression analysis to identify robust predictors. Effect sizes of various outcome variables could be classified as large (g = 1.34 of OCD-symptom change). Predictors of changes in OCD and depressive symptoms were symptom severity at admission and general psychopathological distress. In addition, patients with higher social support and more washing compulsions benefited more from treatment. Subgroup analyses showed a distinct predictor profile of changes in compulsions and obsessions. The results indicate that an evidence-based psychotherapy program for OCD can be effectively implemented in routine inpatient care. In addition to well-established predictors, social support, and washing compulsions in particular were identified as important positive predictors. Specific predictor profiles for changes in obsessions and compulsions are discussed.

Identifiants

DOI: 10.1007/s00406-021-01284-6 PMID: 34218306 PMC: PMC8866294
pubmed: 34218306
doi: 10.1007/s00406-021-01284-6
pii: 10.1007/s00406-021-01284-6
pmc: PMC8866294
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

313-326

Informations de copyright

© 2021. The Author(s).

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Auteurs

Philipp Herzog (P)

Department of Clinical Psychology and Psychotherapy, Philipps-University of Marburg, Gutenbergstraße 18, 35032, Marburg, Germany. philipp.herzog@staff.uni-marburg.de.
ORCID: 0000-0002-8267-2083

Bernhard Osen (B)

Schön-Klinik Bad Bramstedt, Psychosomatic Clinic, Birkenweg 10, 24576, Bad Bramstedt, Germany.

Christian Stierle (C)

Schön-Klinik Bad Bramstedt, Psychosomatic Clinic, Birkenweg 10, 24576, Bad Bramstedt, Germany.

Thomas Middendorf (T)

Schön-Klinik Bad Arolsen, Psychosomatic Clinic, Hofgarten 10, 34454, Bad Arolsen, Germany.

Ulrich Voderholzer (U)

Schön-Klinik Roseneck, Psychosomatic Clinic, Am Roseneck 6, 83209, Prien am Chiemsee, Germany.

Stefan Koch (S)

Schön-Klinik Roseneck, Psychosomatic Clinic, Am Roseneck 6, 83209, Prien am Chiemsee, Germany.

Matthias Feldmann (M)

Department of Clinical Psychology and Psychotherapy, Philipps-University of Marburg, Gutenbergstraße 18, 35032, Marburg, Germany.

Winfried Rief (W)

Department of Clinical Psychology and Psychotherapy, Philipps-University of Marburg, Gutenbergstraße 18, 35032, Marburg, Germany.

Eva-Lotta Brakemeier (EL)

Department of Clinical Psychology and Psychotherapy, Philipps-University of Marburg, Gutenbergstraße 18, 35032, Marburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Determining prognostic variables of treatment...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Determining prognostic variables of treatment...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Trouble obsessionnel compulsif › Determining prognostic variables of treatment...
questionsmedicales.fr › Diagnostic › Pronostic › Determining prognostic variables of treatment...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Determining prognostic variables of treatment...