Variation in urine osmolality throughout pregnancy: a longitudinal, randomized-control trial among women with overweight and obesity.
Birth outcomes
DOHaD
Hydration
Pregnancy
Urine osmolality
Water intake
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
27
01
2021
accepted:
09
06
2021
pubmed:
5
7
2021
medline:
27
1
2022
entrez:
4
7
2021
Statut:
ppublish
Résumé
Water needs increase during pregnancy, and proper hydration is critical for maternal and fetal health. This study characterized weekly hydration status changes throughout pregnancy and examined change in response to a randomized, behavioral intervention. An exploratory analysis tested how underhydration during pregnancy was associated with birth outcomes. The Healthy Mom Zone Study is a longitudinal, randomized-control trial intervention aiming to regulate gestational weight gain (GWG) in pregnant women with overweight/obesity (n = 27). Fourteen women received standard of care; 13 women additionally received weekly guidance on nutrition, physical activity, water intake, and health-promoting behaviors. Hydration status was measured weekly via overnight urine osmolality (Uosm) from ~ 8-36 weeks gestation; underhydration was dichotomized (Uosm ≥ 500 mOsm/kg). Gestational age- and sex-standardized birth weight and length z scores and percentiles were calculated. We used mixed-effect and linear regression models to test covariate-adjusted relationships. No differences existed in Uosm or other characteristics between control and intervention women at baseline. Significant interactions (p = 0.01) between intervention and week of pregnancy on Uosm indicated intervention women maintained lower Uosm, whereas control women had a significant quadratic (inverse-U) relationship and greater Uosm in the second and early third trimesters. Results were consistent across robustness and sensitivity checks. Exploratory analyses suggest underhydration was associated with birth weight, but not length, in opposite ways in the second vs. third trimester. A multi-component behavioral intervention helped women with overweight/obesity maintain better hydration throughout pregnancy. Future studies should confirm birth outcome results as they have important implications for early life nutrition. ClinicalTrials.gov Identifier: NCT03945266; registered May 10, 2019 retrospectively.
Identifiants
pubmed: 34218315
doi: 10.1007/s00394-021-02616-x
pii: 10.1007/s00394-021-02616-x
pmc: PMC8720908
mid: NIHMS1765518
doi:
Banques de données
ClinicalTrials.gov
['NCT03945266']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-140Subventions
Organisme : NHLBI NIH HHS
ID : R56 HL126799
Pays : United States
Organisme : NIH HHS
ID : 1R56HL126799-01
Pays : United States
Organisme : National Institute of Child Health and Human Development
ID : P2CHD041025
Organisme : NICHD NIH HHS
ID : P2C HD041025
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1R01H119245
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL119245
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1R01H119245
Pays : United States
Organisme : NIH HHS
ID : 1R56HL126799-01
Pays : United States
Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
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